New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties
A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brai...
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| Veröffentlicht in: | Biochemistry (Moscow) 2010-02, Vol.75 (2), p.145-150 |
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| creator | Plotnikov, E. Y Silachev, D. N Chupyrkina, A. A Danshina, M. I Jankauskas, S. S Morosanova, M. A Stelmashook, E. V Vasileva, A. K Goryacheva, E. S Pirogov, Y. A Isaev, N. K Zorov, D. B |
| description | A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. An analog of SkQR1 not containing plastoquinone (C12R19) was not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation. |
| doi_str_mv | 10.1134/S0006297910020045 |
| format | Article |
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Y ; Silachev, D. N ; Chupyrkina, A. A ; Danshina, M. I ; Jankauskas, S. S ; Morosanova, M. A ; Stelmashook, E. V ; Vasileva, A. K ; Goryacheva, E. S ; Pirogov, Y. A ; Isaev, N. K ; Zorov, D. B</creator><creatorcontrib>Plotnikov, E. Y ; Silachev, D. N ; Chupyrkina, A. A ; Danshina, M. I ; Jankauskas, S. S ; Morosanova, M. A ; Stelmashook, E. V ; Vasileva, A. K ; Goryacheva, E. S ; Pirogov, Y. A ; Isaev, N. K ; Zorov, D. B</creatorcontrib><description>A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. An analog of SkQR1 not containing plastoquinone (C12R19) was not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297910020045</identifier><identifier>PMID: 20367601</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : SP MAIK Nauka/Interperiodica</publisher><subject>Animals ; Antioxidants ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Brain ; Brain damage ; Brain Ischemia - metabolism ; Brain Ischemia - physiopathology ; Exhibitions ; Intracellular Space - drug effects ; Intracellular Space - metabolism ; Ions ; Ischemia ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney - physiopathology ; Kidney diseases ; Kidneys ; Life Sciences ; Male ; Microbiology ; Mitochondria - drug effects ; Mitochondria - metabolism ; Mitochondrial DNA ; Myoglobinuria - metabolism ; Myoglobinuria - physiopathology ; Nervous System Diseases - complications ; Nervous System Diseases - metabolism ; Nervous System Diseases - physiopathology ; Neuroprotective Agents - pharmacology ; Oxidative Stress - drug effects ; Plastoquinone - analogs & derivatives ; Plastoquinone - pharmacology ; Pyelonephritis - metabolism ; Pyelonephritis - physiopathology ; Rats ; Reactive Oxygen Species - metabolism ; Reperfusion Injury - complications ; Reperfusion Injury - metabolism ; Reperfusion Injury - physiopathology ; Rhodamines - pharmacology</subject><ispartof>Biochemistry (Moscow), 2010-02, Vol.75 (2), p.145-150</ispartof><rights>Pleiades Publishing, Ltd. 2010</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-326ca7125b777cdf56057e787b7daf2da5d6a55a1fdbddc352c0ff4d855a0dd73</citedby><cites>FETCH-LOGICAL-c509t-326ca7125b777cdf56057e787b7daf2da5d6a55a1fdbddc352c0ff4d855a0dd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297910020045$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297910020045$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20367601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plotnikov, E. Y</creatorcontrib><creatorcontrib>Silachev, D. N</creatorcontrib><creatorcontrib>Chupyrkina, A. A</creatorcontrib><creatorcontrib>Danshina, M. I</creatorcontrib><creatorcontrib>Jankauskas, S. S</creatorcontrib><creatorcontrib>Morosanova, M. A</creatorcontrib><creatorcontrib>Stelmashook, E. V</creatorcontrib><creatorcontrib>Vasileva, A. K</creatorcontrib><creatorcontrib>Goryacheva, E. S</creatorcontrib><creatorcontrib>Pirogov, Y. A</creatorcontrib><creatorcontrib>Isaev, N. K</creatorcontrib><creatorcontrib>Zorov, D. B</creatorcontrib><title>New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. An analog of SkQR1 not containing plastoquinone (C12R19) was not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Brain</subject><subject>Brain damage</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - physiopathology</subject><subject>Exhibitions</subject><subject>Intracellular Space - drug effects</subject><subject>Intracellular Space - metabolism</subject><subject>Ions</subject><subject>Ischemia</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Microbiology</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondrial DNA</subject><subject>Myoglobinuria - metabolism</subject><subject>Myoglobinuria - physiopathology</subject><subject>Nervous System Diseases - complications</subject><subject>Nervous System Diseases - metabolism</subject><subject>Nervous System Diseases - physiopathology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Oxidative Stress - drug effects</subject><subject>Plastoquinone - analogs & derivatives</subject><subject>Plastoquinone - pharmacology</subject><subject>Pyelonephritis - metabolism</subject><subject>Pyelonephritis - physiopathology</subject><subject>Rats</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Reperfusion Injury - complications</subject><subject>Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - physiopathology</subject><subject>Rhodamines - pharmacology</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFv1DAQhS0EokvhB3CBCA6cUsZ2HCfHqqKAVMFhqcTNcuxx1iXrLHZS6L_HUQqogJAPtt9873msIeQphRNKefV6CwA1a2VLARhAJe6RDa2hKTlUcJ9slnK51I_Io5SuYKFa_pAcMeC1rIFuyOcP-K3sMWDUkx9Dsf0yD9rs8LrIt1Tg953v_ORDXwQ87OJ4iOOEZvLXWOhgszjf0fLxgHHymB6TB04PCZ_c7sfk8vzNp7N35cXHt-_PTi9KI6CdSs5qoyVlopNSGutEDUKibGQnrXbMamFrLYSmznbWGi6YAecq22QNrJX8mLxac_PTX2dMk9r7ZHAYdMBxTkpyzmX-tcjkiz_Iq3GOITenGGe8laKtMvRyhXo9oPLBjVPUZolUp7wSUlZNSzN18g8qL4t7b8aAzmf9joGuBhPHlCI6dYh-r-ONoqCWWaq_Zpk9z277nbs92l-On8PLAFuBlEuhx_j7Q_9Lfb6anB6V7qNP6nLLchrQhvKmkvwHfHWxqw</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Plotnikov, E. 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Y</au><au>Silachev, D. N</au><au>Chupyrkina, A. A</au><au>Danshina, M. I</au><au>Jankauskas, S. S</au><au>Morosanova, M. A</au><au>Stelmashook, E. V</au><au>Vasileva, A. K</au><au>Goryacheva, E. S</au><au>Pirogov, Y. A</au><au>Isaev, N. K</au><au>Zorov, D. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>75</volume><issue>2</issue><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. 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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Antioxidants Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Brain Brain damage Brain Ischemia - metabolism Brain Ischemia - physiopathology Exhibitions Intracellular Space - drug effects Intracellular Space - metabolism Ions Ischemia Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney - physiopathology Kidney diseases Kidneys Life Sciences Male Microbiology Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Myoglobinuria - metabolism Myoglobinuria - physiopathology Nervous System Diseases - complications Nervous System Diseases - metabolism Nervous System Diseases - physiopathology Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Plastoquinone - analogs & derivatives Plastoquinone - pharmacology Pyelonephritis - metabolism Pyelonephritis - physiopathology Rats Reactive Oxygen Species - metabolism Reperfusion Injury - complications Reperfusion Injury - metabolism Reperfusion Injury - physiopathology Rhodamines - pharmacology |
| title | New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties |
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