Phase II, Randomized Trial to Compare Anastrozole Combined with Gefitinib or Placebo in Postmenopausal Women with Hormone Receptor-Positive Metastatic Breast Cancer

This phase II randomized trial evaluated the efficacy and tolerability of anastrozole combined with gefitinib or anastrozole with placebo in women with hormone receptor-positive metastatic breast cancer (MBC). Postmenopausal women with hormone receptor-positive measurable or evaluable MBC who had no...

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Veröffentlicht in:	Clinical cancer research 2010-03, Vol.16 (6), p.1904-1914
Hauptverfasser:	CRISTOFANILLI, Massimo, VALERO, Vicente, CORA, Elsa M, ANDERSON, Elizabeth, MAGILL, Patrick J, MANGALIK, Aroop, ROYCE, Melanie, RABINOWITZ, Ian, ARENA, Francis P, KROENER, Joan F, CURCIO, Elizabeth, WATKINS, Claire, BACUS, Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Double-Blind Method Female Gynecology. Andrology. Obstetrics Humans Lymphatic Metastasis Mammary gland diseases Medical sciences Middle Aged Neoplasm Metastasis Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Nitriles - administration & dosage Pharmacology. Drug treatments Postmenopause Prospective Studies Quinazolines - administration & dosage Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Survival Rate Tissue Distribution Treatment Outcome Triazoles - administration & dosage Tumors
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