Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure

Interleukin-12 (IL-12) gene therapy is expected to be effective against cancers because it primes the immune system for cancer cells. In this therapy, it is important to induce IL-12 gene expression in the tumor tissue. Sonoporation is an attractive technique for developing non-invasive and non-vira...

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Veröffentlicht in:	Journal of controlled release 2010-03, Vol.142 (2), p.245-250
Hauptverfasser:	Suzuki, Ryo, Namai, Eisuke, Oda, Yusuke, Nishiie, Norihito, Otake, Shota, Koshima, Risa, Hirata, Keiichi, Taira, Yuichiro, Utoguchi, Naoki, Negishi, Yoichi, Nakagawa, Shinsaku, Maruyama, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Carcinoma - therapy Cavitation CD8 antigen Controlled release DNA DNA - administration & dosage Expression vectors Female Gene Expression Gene therapy Gene transfer Gene Transfer Techniques Genetic Therapy - methods imaging Immune system Interleukin 12 Interleukin-12 - genetics Leukocyte migration Liposomes Liposomes - chemistry Lymphocytes T Mice Mice, Inbred BALB C Mice, Nude Ovarian Neoplasms - therapy Plasmids Plasmids - administration & dosage Transfection Tumors Ultrasonics Ultrasound
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