Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs

Alterations in the physicochemical characteristics of peptide drugs can transform their biological and pharmaceutical features. In the present study, we explored the potentials of lithocholic acid (LCA)-modified exendin-4 derivatives as novel long-acting GLP-1 receptor agonists. Exendin-4 was modifi...

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Veröffentlicht in:	Journal of controlled release 2010-03, Vol.142 (2), p.206-213
Hauptverfasser:	SU YOUNG CHAE, JIN, Cheng-Hao, JAE HEE SHIN, SON, Sohee, TAE HYUNG KIM, LEE, Seulki, YU SEOK YOUN, BYUN, Youngro, LEE, Myung-Shik, KANG CHOON LEE
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Animals Beta cells Biological and medical sciences Controlled release Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Drugs General pharmacology Glucose High-performance liquid chromatography Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacokinetics Hypoglycemic Agents - therapeutic use Kinetics Lithocholic Acid - chemistry Lysine Male Medical sciences Mice Mice, Inbred C57BL nanoparticles Pancreas Peptides - chemistry Peptides - pharmacokinetics Peptides - therapeutic use Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacokinetics Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Venoms - chemistry Venoms - pharmacokinetics Venoms - therapeutic use
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