Incidence and evolution of oxaliplatin-induced peripheral sensory neuropathy in diabetic patients with colorectal cancer: a pooled analysis of three phase III studies

The purpose of this study was to determine whether the presence of diabetes mellitus (DM) influences the incidence, severity, and/or course of peripheral sensory neuropathy (PSN) after oxaliplatin (FOLFOX) therapy in patients with colorectal cancer (CRC). A retrospective pooled analysis incorporatin...

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Veröffentlicht in:	Annals of oncology 2010-04, Vol.21 (4), p.754-758
Hauptverfasser:	Ramanathan, R.K., Rothenberg, M.L., de Gramont, A., Tournigand, C., Goldberg, R.M., Gupta, S., André, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Carcinoma - complications Carcinoma - drug therapy Carcinoma - pathology Clinical Trials, Phase III as Topic - statistics & numerical data colon cancer Colorectal Neoplasms - complications Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Diabetes Complications - chemically induced Diabetes Complications - drug therapy Diabetes Complications - pathology diabetes mellitus Diabetic Neuropathies - chemically induced Diabetic Neuropathies - epidemiology Diabetic Neuropathies - pathology Disease Progression Female FOLFOX Humans Incidence Male Middle Aged Multicenter Studies as Topic neuropathy Organoplatinum Compounds - adverse effects Organoplatinum Compounds - therapeutic use Oxaliplatin Randomized Controlled Trials as Topic - statistics & numerical data Retrospective Studies Sensory Receptor Cells - pathology
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