Negative regulation of TCR signaling and T-cell activation by selective protein degradation

Protein degradation was previously considered to be a nonspecific cellular process that eradicated abnormal or damaged proteins. Current evidence indicates, however, that T cells use this mechanism to selectively eliminate activated T-cell receptors (TCRs) and signaling molecules, and consequently c...

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Veröffentlicht in:	Current opinion in immunology 2003-06, Vol.15 (3), p.315-320
Hauptverfasser:	Jang, Ihn-Kyung, Gu, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD28 Antigens - physiology Down-Regulation Lymphocyte Activation Mice Models, Immunological Protein-Tyrosine Kinases - metabolism Proteins - metabolism Receptors, Antigen, T-Cell - physiology Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - metabolism Ubiquitin-Conjugating Enzymes - metabolism
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