Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway

The transcription factor nuclear factor kappaB (NF-kappaB) induces the expression of various inflammatory genes. In the common NF-kappaB signaling pathway, peperomin E and 2,6-didehydropeperomin B inhibited IkappaB degradation upon stimulation with TNF-alpha or interleukin-1. Consistent with these r...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (15), p.4084-4087
Hauptverfasser:	Tsutsui, Chieko, Yamada, Yuriko, Ando, Masayoshi, Toyama, Daisuke, Wu, Jian-Lin, Wang, Liyan, Taketani, Shigeru, Kataoka, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Benzodioxoles - chemical synthesis Benzodioxoles - pharmacology Cell Line, Tumor Chemistry, Pharmaceutical - methods Drug Design Gene Expression Regulation Humans Inflammation - drug therapy Interleukin-1 - metabolism Models, Chemical NF-kappa B - metabolism Phosphorylation Signal Transduction Structure-Activity Relationship Tumor Necrosis Factor-alpha - metabolism
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