Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway
The transcription factor nuclear factor kappaB (NF-kappaB) induces the expression of various inflammatory genes. In the common NF-kappaB signaling pathway, peperomin E and 2,6-didehydropeperomin B inhibited IkappaB degradation upon stimulation with TNF-alpha or interleukin-1. Consistent with these r...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (15), p.4084-4087 |
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| container_end_page | 4087 |
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| container_issue | 15 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 19 |
| creator | Tsutsui, Chieko Yamada, Yuriko Ando, Masayoshi Toyama, Daisuke Wu, Jian-Lin Wang, Liyan Taketani, Shigeru Kataoka, Takao |
| description | The transcription factor nuclear factor kappaB (NF-kappaB) induces the expression of various inflammatory genes. In the common NF-kappaB signaling pathway, peperomin E and 2,6-didehydropeperomin B inhibited IkappaB degradation upon stimulation with TNF-alpha or interleukin-1. Consistent with these results, peperomin E and 2,6-didehydropeperomin B blocked the TNF-alpha-induced activation of IkappaB kinase, while they had no direct effect on the IkappaB kinase activity. Our present results clearly demonstrate that peperomins inhibit the NF-kappaB signaling pathway by blocking IkappaB kinase activation. |
| doi_str_mv | 10.1016/j.bmcl.2009.06.029 |
| format | Article |
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| subjects | Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Benzodioxoles - chemical synthesis Benzodioxoles - pharmacology Cell Line, Tumor Chemistry, Pharmaceutical - methods Drug Design Gene Expression Regulation Humans Inflammation - drug therapy Interleukin-1 - metabolism Models, Chemical NF-kappa B - metabolism Phosphorylation Signal Transduction Structure-Activity Relationship Tumor Necrosis Factor-alpha - metabolism |
| title | Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway |
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