ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle
Rat ERK6, also known as SAPK3 and p38γ, exhibits a distinct pattern of expression during muscle development in vitro and in vivo. Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture. This is in contrast to the e...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2003-06, Vol.306 (1), p.163-168 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Tortorella, Lori L Lin, Connie B Pilch, Paul F |
| description | Rat ERK6, also known as SAPK3 and p38γ, exhibits a distinct pattern of expression during muscle development in vitro and in vivo. Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture. This is in contrast to the expression of other MAP kinase family members, namely p42/p44 MAPK and p38 MAPK, whose expression does not change during myogenesis. Similar results are observed in vivo where ERK6 mRNA levels increase with post-natal development in rat hindlimb mixed muscle samples. These results delineate a distinct pattern of ERK6 expression in mature skeletal muscle cells and suggest a specific role for ERK6 in muscle development or muscle function. |
| doi_str_mv | 10.1016/S0006-291X(03)00936-7 |
| format | Article |
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Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture. This is in contrast to the expression of other MAP kinase family members, namely p42/p44 MAPK and p38 MAPK, whose expression does not change during myogenesis. Similar results are observed in vivo where ERK6 mRNA levels increase with post-natal development in rat hindlimb mixed muscle samples. These results delineate a distinct pattern of ERK6 expression in mature skeletal muscle cells and suggest a specific role for ERK6 in muscle development or muscle function.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(03)00936-7</identifier><identifier>PMID: 12788083</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Differentiation ; Cell Line ; Cloning, Molecular ; ERK ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Enzymologic ; Kinase ; MAP Kinase Signaling System ; MAPK ; Mitogen-Activated Protein Kinase 1 - genetics ; Mitogen-Activated Protein Kinase 12 ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinases - genetics ; Muscle cell line ; Muscle, Skeletal - enzymology ; Muscle, Skeletal - growth & development ; Myoblasts - cytology ; Myoblasts - enzymology ; p38 Mitogen-Activated Protein Kinases ; Rats ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signaling ; Skeletal muscle ; Tissue Distribution</subject><ispartof>Biochemical and biophysical research communications, 2003-06, Vol.306 (1), p.163-168</ispartof><rights>2003 Elsevier Science (USA)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-5ff65bcec353741d5a9a60b056f23518bd507faa0c7fa45a39f883cef555c06b3</citedby><cites>FETCH-LOGICAL-c392t-5ff65bcec353741d5a9a60b056f23518bd507faa0c7fa45a39f883cef555c06b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-291X(03)00936-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12788083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tortorella, Lori L</creatorcontrib><creatorcontrib>Lin, Connie B</creatorcontrib><creatorcontrib>Pilch, Paul F</creatorcontrib><title>ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Rat ERK6, also known as SAPK3 and p38γ, exhibits a distinct pattern of expression during muscle development in vitro and in vivo. Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture. This is in contrast to the expression of other MAP kinase family members, namely p42/p44 MAPK and p38 MAPK, whose expression does not change during myogenesis. Similar results are observed in vivo where ERK6 mRNA levels increase with post-natal development in rat hindlimb mixed muscle samples. These results delineate a distinct pattern of ERK6 expression in mature skeletal muscle cells and suggest a specific role for ERK6 in muscle development or muscle function.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Cell Line</subject><subject>Cloning, Molecular</subject><subject>ERK</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Kinase</subject><subject>MAP Kinase Signaling System</subject><subject>MAPK</subject><subject>Mitogen-Activated Protein Kinase 1 - genetics</subject><subject>Mitogen-Activated Protein Kinase 12</subject><subject>Mitogen-Activated Protein Kinase 3</subject><subject>Mitogen-Activated Protein Kinases - genetics</subject><subject>Muscle cell line</subject><subject>Muscle, Skeletal - enzymology</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Myoblasts - cytology</subject><subject>Myoblasts - enzymology</subject><subject>p38 Mitogen-Activated Protein Kinases</subject><subject>Rats</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signaling</subject><subject>Skeletal muscle</subject><subject>Tissue Distribution</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaCsECwC4zh24hVCVXmISoiXxM5ynAkKOEmxk4r-PelDsOxmZnHPzJUOIccULihQcfkCACKMJH0_A3YOIJkIkx0ypCAhjCjEu2T4hwzIgfefAJTGQu6TAY2SNIWUDcnT5PlBBKUP8Gfm0HvMg7IOdJDjHG0zq7ButbWLwOFHZ3Xbx5Wua3RLyjV5Hwf-Cy32VFB13lg8JHuFth6PNntE3m4mr-O7cPp4ez--noaGyagNeVEInhk0jLMkpjnXUgvIgIsiYpymWc4hKbQG08-YayaLNGUGC865AZGxETld_5255rtD36qq9Aat1TU2nVcJY0zElG4FaZpIFiVxD_I1aFzjvcNCzVxZabdQFNRSulpJV0ujCphaSe97RuRkU9BlFeb_VxvLPXC1BrD3MS_RKW9KrA3mpUPTqrwpt1T8An9kkbQ</recordid><startdate>20030620</startdate><enddate>20030620</enddate><creator>Tortorella, Lori L</creator><creator>Lin, Connie B</creator><creator>Pilch, Paul F</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20030620</creationdate><title>ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle</title><author>Tortorella, Lori L ; Lin, Connie B ; Pilch, Paul F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-5ff65bcec353741d5a9a60b056f23518bd507faa0c7fa45a39f883cef555c06b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Cell Line</topic><topic>Cloning, Molecular</topic><topic>ERK</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Kinase</topic><topic>MAP Kinase Signaling System</topic><topic>MAPK</topic><topic>Mitogen-Activated Protein Kinase 1 - genetics</topic><topic>Mitogen-Activated Protein Kinase 12</topic><topic>Mitogen-Activated Protein Kinase 3</topic><topic>Mitogen-Activated Protein Kinases - genetics</topic><topic>Muscle cell line</topic><topic>Muscle, Skeletal - enzymology</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Myoblasts - cytology</topic><topic>Myoblasts - enzymology</topic><topic>p38 Mitogen-Activated Protein Kinases</topic><topic>Rats</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signaling</topic><topic>Skeletal muscle</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tortorella, Lori L</creatorcontrib><creatorcontrib>Lin, Connie B</creatorcontrib><creatorcontrib>Pilch, Paul F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tortorella, Lori L</au><au>Lin, Connie B</au><au>Pilch, Paul F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2003-06-20</date><risdate>2003</risdate><volume>306</volume><issue>1</issue><spage>163</spage><epage>168</epage><pages>163-168</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Rat ERK6, also known as SAPK3 and p38γ, exhibits a distinct pattern of expression during muscle development in vitro and in vivo. Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture. This is in contrast to the expression of other MAP kinase family members, namely p42/p44 MAPK and p38 MAPK, whose expression does not change during myogenesis. Similar results are observed in vivo where ERK6 mRNA levels increase with post-natal development in rat hindlimb mixed muscle samples. These results delineate a distinct pattern of ERK6 expression in mature skeletal muscle cells and suggest a specific role for ERK6 in muscle development or muscle function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12788083</pmid><doi>10.1016/S0006-291X(03)00936-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Cell Differentiation Cell Line Cloning, Molecular ERK Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Kinase MAP Kinase Signaling System MAPK Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 12 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - genetics Muscle cell line Muscle, Skeletal - enzymology Muscle, Skeletal - growth & development Myoblasts - cytology Myoblasts - enzymology p38 Mitogen-Activated Protein Kinases Rats RNA, Messenger - genetics RNA, Messenger - metabolism Signaling Skeletal muscle Tissue Distribution |
| title | ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle |
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