Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy
Proton-decoupled phosphorus-31 heart spectroscopy was performed in healthy subjects (n = 9) and patients with dilated cardiomyopathy (DCM, n = 9) or hypertrophic cardiomyopathy (HCM, n = 8). The phosphocreatine (PCr)-to-adenosine triphosphate ratio (+/- one standard deviation) after correction for b...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 1992-11, Vol.2 (6), p.711-719 |
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| creator | de Roos, A Doornbos, J Luyten, P R Oosterwaal, L J van der Wall, E E den Hollander, J A |
| description | Proton-decoupled phosphorus-31 heart spectroscopy was performed in healthy subjects (n = 9) and patients with dilated cardiomyopathy (DCM, n = 9) or hypertrophic cardiomyopathy (HCM, n = 8). The phosphocreatine (PCr)-to-adenosine triphosphate ratio (+/- one standard deviation) after correction for blood contribution and partial saturation was significantly lower in HCM patients relative to the control subjects (1.32 +/- 0.29 vs 1.65 +/- 0.26, P < .05) but not in DCM patients (1.52 +/- 0.58 vs 1.65 +/- 0.26). The inorganic phosphate (Pi) peak was resolved only in patients with the highest spectral quality. Myocardial pH was lower in HCM patients (n = 6) relative to control subjects (n = 4) (7.07 +/- 0.07 vs 7.15 +/- 0.03, P < .05). The Pi/PCr ratio was higher in DCM (n = 3) and HCM (n = 6) patients relative to control subjects (n = 4) (0.29 +/- 0.06 and 0.20 +/- 0.04, respectively, vs 0.14 +/- 0.06; P < .05). Elevated phosphodiester signal in DCM patients correlated with 2,3-diphosphoglycerate signal (r = .94), reflecting blood pool contamination. P-31 spectroscopy enabled detection of abnormalities in cardiac metabolism and determination of pH in patients with HCM and DCM. |
| doi_str_mv | 10.1002/jmri.1880020616 |
| format | Article |
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The phosphocreatine (PCr)-to-adenosine triphosphate ratio (+/- one standard deviation) after correction for blood contribution and partial saturation was significantly lower in HCM patients relative to the control subjects (1.32 +/- 0.29 vs 1.65 +/- 0.26, P < .05) but not in DCM patients (1.52 +/- 0.58 vs 1.65 +/- 0.26). The inorganic phosphate (Pi) peak was resolved only in patients with the highest spectral quality. Myocardial pH was lower in HCM patients (n = 6) relative to control subjects (n = 4) (7.07 +/- 0.07 vs 7.15 +/- 0.03, P < .05). The Pi/PCr ratio was higher in DCM (n = 3) and HCM (n = 6) patients relative to control subjects (n = 4) (0.29 +/- 0.06 and 0.20 +/- 0.04, respectively, vs 0.14 +/- 0.06; P < .05). Elevated phosphodiester signal in DCM patients correlated with 2,3-diphosphoglycerate signal (r = .94), reflecting blood pool contamination. P-31 spectroscopy enabled detection of abnormalities in cardiac metabolism and determination of pH in patients with HCM and DCM.</description><identifier>ISSN: 1053-1807</identifier><identifier>DOI: 10.1002/jmri.1880020616</identifier><identifier>PMID: 1446116</identifier><language>eng</language><publisher>United States</publisher><subject>Adenosine Triphosphate - metabolism ; Adult ; Cardiomyopathy, Dilated - metabolism ; Cardiomyopathy, Hypertrophic - metabolism ; Diphosphoglyceric Acids - metabolism ; Female ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Myocardium - metabolism ; Phosphates - metabolism ; Phosphocreatine - metabolism ; Reference Values</subject><ispartof>Journal of magnetic resonance imaging, 1992-11, Vol.2 (6), p.711-719</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1446116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Roos, A</creatorcontrib><creatorcontrib>Doornbos, J</creatorcontrib><creatorcontrib>Luyten, P R</creatorcontrib><creatorcontrib>Oosterwaal, L J</creatorcontrib><creatorcontrib>van der Wall, E E</creatorcontrib><creatorcontrib>den Hollander, J A</creatorcontrib><title>Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Proton-decoupled phosphorus-31 heart spectroscopy was performed in healthy subjects (n = 9) and patients with dilated cardiomyopathy (DCM, n = 9) or hypertrophic cardiomyopathy (HCM, n = 8). The phosphocreatine (PCr)-to-adenosine triphosphate ratio (+/- one standard deviation) after correction for blood contribution and partial saturation was significantly lower in HCM patients relative to the control subjects (1.32 +/- 0.29 vs 1.65 +/- 0.26, P < .05) but not in DCM patients (1.52 +/- 0.58 vs 1.65 +/- 0.26). The inorganic phosphate (Pi) peak was resolved only in patients with the highest spectral quality. Myocardial pH was lower in HCM patients (n = 6) relative to control subjects (n = 4) (7.07 +/- 0.07 vs 7.15 +/- 0.03, P < .05). The Pi/PCr ratio was higher in DCM (n = 3) and HCM (n = 6) patients relative to control subjects (n = 4) (0.29 +/- 0.06 and 0.20 +/- 0.04, respectively, vs 0.14 +/- 0.06; P < .05). Elevated phosphodiester signal in DCM patients correlated with 2,3-diphosphoglycerate signal (r = .94), reflecting blood pool contamination. P-31 spectroscopy enabled detection of abnormalities in cardiac metabolism and determination of pH in patients with HCM and DCM.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Adult</subject><subject>Cardiomyopathy, Dilated - metabolism</subject><subject>Cardiomyopathy, Hypertrophic - metabolism</subject><subject>Diphosphoglyceric Acids - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardium - metabolism</subject><subject>Phosphates - metabolism</subject><subject>Phosphocreatine - metabolism</subject><subject>Reference Values</subject><issn>1053-1807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkD1PwzAQhj2ASinMTEie2FJ8ceIkbKjiSyoCIZgjx74orpLYxK5QVn45Ru10Nzzvo7uXkCtga2Asvd0Nk1lDWcadCRAnZAks5wmUrDgj597vGGNVleULsoAsEwBiSX43ctJGKjpgkI3tjR-oGamTweAYPP0xoaPa9DKgpnLUtJsdTmGyrjOKqv-wHWYb-W6-o9J79H6IyUPQTTbYMdGo7N710fCecKCvH9Q7VFHilXXzBTltZe_x8jhX5Ovx4XPznGzfnl4299vEAS9DArpq8qISaZ6xtoRCKdHEh0ArqbnQyHSZV6LASnLWNCmytGyrTAJikyPIlq_IzcEbr_reow_1YLzCvpcj2r2vC8654LyI4PUR3DcD6tpNZpDTXB9L43-JYnAr</recordid><startdate>199211</startdate><enddate>199211</enddate><creator>de Roos, A</creator><creator>Doornbos, J</creator><creator>Luyten, P R</creator><creator>Oosterwaal, L J</creator><creator>van der Wall, E E</creator><creator>den Hollander, J A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199211</creationdate><title>Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy</title><author>de Roos, A ; Doornbos, J ; Luyten, P R ; Oosterwaal, L J ; van der Wall, E E ; den Hollander, J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p138t-1d9b57962540f817cc6b0001dcad36de0d85967e9a30bb2e028f94a1eeb5e1af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Adult</topic><topic>Cardiomyopathy, Dilated - metabolism</topic><topic>Cardiomyopathy, Hypertrophic - metabolism</topic><topic>Diphosphoglyceric Acids - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardium - metabolism</topic><topic>Phosphates - metabolism</topic><topic>Phosphocreatine - metabolism</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Roos, A</creatorcontrib><creatorcontrib>Doornbos, J</creatorcontrib><creatorcontrib>Luyten, P R</creatorcontrib><creatorcontrib>Oosterwaal, L J</creatorcontrib><creatorcontrib>van der Wall, E E</creatorcontrib><creatorcontrib>den Hollander, J A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Roos, A</au><au>Doornbos, J</au><au>Luyten, P R</au><au>Oosterwaal, L J</au><au>van der Wall, E E</au><au>den Hollander, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>1992-11</date><risdate>1992</risdate><volume>2</volume><issue>6</issue><spage>711</spage><epage>719</epage><pages>711-719</pages><issn>1053-1807</issn><abstract>Proton-decoupled phosphorus-31 heart spectroscopy was performed in healthy subjects (n = 9) and patients with dilated cardiomyopathy (DCM, n = 9) or hypertrophic cardiomyopathy (HCM, n = 8). The phosphocreatine (PCr)-to-adenosine triphosphate ratio (+/- one standard deviation) after correction for blood contribution and partial saturation was significantly lower in HCM patients relative to the control subjects (1.32 +/- 0.29 vs 1.65 +/- 0.26, P < .05) but not in DCM patients (1.52 +/- 0.58 vs 1.65 +/- 0.26). The inorganic phosphate (Pi) peak was resolved only in patients with the highest spectral quality. Myocardial pH was lower in HCM patients (n = 6) relative to control subjects (n = 4) (7.07 +/- 0.07 vs 7.15 +/- 0.03, P < .05). The Pi/PCr ratio was higher in DCM (n = 3) and HCM (n = 6) patients relative to control subjects (n = 4) (0.29 +/- 0.06 and 0.20 +/- 0.04, respectively, vs 0.14 +/- 0.06; P < .05). Elevated phosphodiester signal in DCM patients correlated with 2,3-diphosphoglycerate signal (r = .94), reflecting blood pool contamination. P-31 spectroscopy enabled detection of abnormalities in cardiac metabolism and determination of pH in patients with HCM and DCM.</abstract><cop>United States</cop><pmid>1446116</pmid><doi>10.1002/jmri.1880020616</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenosine Triphosphate - metabolism Adult Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Hypertrophic - metabolism Diphosphoglyceric Acids - metabolism Female Humans Magnetic Resonance Spectroscopy Male Middle Aged Myocardium - metabolism Phosphates - metabolism Phosphocreatine - metabolism Reference Values |
| title | Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy |
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