Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle
Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are essential for ovarian follicular growth in sheep, whereas only GDF9 is essential in mice suggesting that the roles of these oocyte-derived growth factors differ among species. At present, however, there is only limi...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2009-07, Vol.138 (1), p.107-114 |
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| creator | Juengel, Jennifer L Hudson, Norma L Berg, Martin Hamel, Keith Smith, Peter Lawrence, Stephen B Whiting, Lynda McNatty, Kenneth P |
| description | Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are essential for ovarian follicular growth in sheep, whereas only GDF9 is essential in mice suggesting that the roles of these oocyte-derived growth factors differ among species. At present, however, there is only limited information on the action of BMP15 and GDF9 in other species. Thus, the aim of this experiment was to determine the effect of neutralizing GDF9 and/or BMP15 in vivo on ovarian follicular development and ovulation rate in cattle through active immunization using the mature regions of the proteins or peptides from the N-terminal area of mature regions. Immunization with the BMP15 peptide, with or without GDF9 peptide, significantly altered (increased or decreased) ovulation rate. In some animals, there were no functional corpora lutea (CL), whereas in others up to four CL were observed. From morphometric examination of the ovaries, immunization with GDF9 and/or BMP15 reduced the level of ovarian follicular development as assessed by a reduced proportion of the ovarian section occupied by antral follicles. In addition, immunization against GDF9 and/or BMP15 peptides reduced follicular size to |
| doi_str_mv | 10.1530/REP-09-0009 |
| format | Article |
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At present, however, there is only limited information on the action of BMP15 and GDF9 in other species. Thus, the aim of this experiment was to determine the effect of neutralizing GDF9 and/or BMP15 in vivo on ovarian follicular development and ovulation rate in cattle through active immunization using the mature regions of the proteins or peptides from the N-terminal area of mature regions. Immunization with the BMP15 peptide, with or without GDF9 peptide, significantly altered (increased or decreased) ovulation rate. In some animals, there were no functional corpora lutea (CL), whereas in others up to four CL were observed. From morphometric examination of the ovaries, immunization with GDF9 and/or BMP15 reduced the level of ovarian follicular development as assessed by a reduced proportion of the ovarian section occupied by antral follicles. In addition, immunization against GDF9 and/or BMP15 peptides reduced follicular size to <25% of that in the controls. In conclusion, immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle. Thus, as has been observed in sheep, both GDF9 and BMP15 appear to be key regulators of normal follicular development and ovulation rate in cattle.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/REP-09-0009</identifier><identifier>PMID: 19439562</identifier><language>eng</language><publisher>England: BioScientifica</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Animals ; Antibodies - blood ; Antigens - administration & dosage ; Antigens - immunology ; Antigens - metabolism ; Bone Morphogenetic Protein 15 - administration & dosage ; Bone Morphogenetic Protein 15 - immunology ; Bone Morphogenetic Protein 15 - metabolism ; Cattle - immunology ; Cattle - metabolism ; Female ; Growth Differentiation Factor 9 - administration & dosage ; Growth Differentiation Factor 9 - immunology ; Growth Differentiation Factor 9 - metabolism ; Immunization - veterinary ; Ovarian Follicle - immunology ; Ovarian Follicle - metabolism ; Ovary - immunology ; Ovary - metabolism ; Ovulation</subject><ispartof>Reproduction (Cambridge, England), 2009-07, Vol.138 (1), p.107-114</ispartof><rights>2009 Society for Reproduction and Fertility</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b532t-d82428eea6ee5153144b8399f0dff0d8410b0b49a0360f9040f554e629c8be493</citedby><cites>FETCH-LOGICAL-b532t-d82428eea6ee5153144b8399f0dff0d8410b0b49a0360f9040f554e629c8be493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19439562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juengel, Jennifer L</creatorcontrib><creatorcontrib>Hudson, Norma L</creatorcontrib><creatorcontrib>Berg, Martin</creatorcontrib><creatorcontrib>Hamel, Keith</creatorcontrib><creatorcontrib>Smith, Peter</creatorcontrib><creatorcontrib>Lawrence, Stephen B</creatorcontrib><creatorcontrib>Whiting, Lynda</creatorcontrib><creatorcontrib>McNatty, Kenneth P</creatorcontrib><title>Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are essential for ovarian follicular growth in sheep, whereas only GDF9 is essential in mice suggesting that the roles of these oocyte-derived growth factors differ among species. At present, however, there is only limited information on the action of BMP15 and GDF9 in other species. Thus, the aim of this experiment was to determine the effect of neutralizing GDF9 and/or BMP15 in vivo on ovarian follicular development and ovulation rate in cattle through active immunization using the mature regions of the proteins or peptides from the N-terminal area of mature regions. Immunization with the BMP15 peptide, with or without GDF9 peptide, significantly altered (increased or decreased) ovulation rate. In some animals, there were no functional corpora lutea (CL), whereas in others up to four CL were observed. From morphometric examination of the ovaries, immunization with GDF9 and/or BMP15 reduced the level of ovarian follicular development as assessed by a reduced proportion of the ovarian section occupied by antral follicles. In addition, immunization against GDF9 and/or BMP15 peptides reduced follicular size to <25% of that in the controls. In conclusion, immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle. Thus, as has been observed in sheep, both GDF9 and BMP15 appear to be key regulators of normal follicular development and ovulation rate in cattle.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Animals</subject><subject>Antibodies - blood</subject><subject>Antigens - administration & dosage</subject><subject>Antigens - immunology</subject><subject>Antigens - metabolism</subject><subject>Bone Morphogenetic Protein 15 - administration & dosage</subject><subject>Bone Morphogenetic Protein 15 - immunology</subject><subject>Bone Morphogenetic Protein 15 - metabolism</subject><subject>Cattle - immunology</subject><subject>Cattle - metabolism</subject><subject>Female</subject><subject>Growth Differentiation Factor 9 - administration & dosage</subject><subject>Growth Differentiation Factor 9 - immunology</subject><subject>Growth Differentiation Factor 9 - metabolism</subject><subject>Immunization - veterinary</subject><subject>Ovarian Follicle - immunology</subject><subject>Ovarian Follicle - metabolism</subject><subject>Ovary - immunology</subject><subject>Ovary - metabolism</subject><subject>Ovulation</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO1DAQRSMEYh6wYg_ezWIUphw_Ei_RqHlII4GAWVtOUk4bdezGdmYEf8Bf4yaNQCxYlKqkOveqfF1Vzyi8pILB1cfNhxpUDQDqQXVKW07rtlPqYZl5CzWVjTypzlL6AkBF18rH1QlVnCkhm9Pqx8ZaHHIiwRIzZHeHxM3z4t13k13wxEzG-ZTJFMN93pLRFTyiz25d26IJkShi_HhVhj54JHOI-22Y0GN2A9nHkNF5QgUpgnBnojNFuPjhl0PZDCbnHT6pHlmzS_j02M-r29ebz9dv65v3b95dv7qpe8GaXI9dw5sO0UhEUd5POe87ppSF0ZbqOIUeeq4MMAlWAQcrBEfZqKHrkSt2Xl2svuWwrwumrGeXBtztjMewJN0yxmRDJS_k5UoOMaQU0ep9dLOJ3zQFfYhel-g1KH2IvtDPj75LP-P4hz1mXYBmBbZu2t67iLp3IQ3ukKZ1g_nb9feHFtGLVWRN0GaKLunbTw1QBlQK6DpRCLoS_7j979afhIqp_A</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Juengel, Jennifer L</creator><creator>Hudson, Norma L</creator><creator>Berg, Martin</creator><creator>Hamel, Keith</creator><creator>Smith, Peter</creator><creator>Lawrence, Stephen B</creator><creator>Whiting, Lynda</creator><creator>McNatty, Kenneth P</creator><general>BioScientifica</general><general>BioScientifica Ltd</general><general>Society for Reproduction and Fertility</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle</title><author>Juengel, Jennifer L ; Hudson, Norma L ; Berg, Martin ; Hamel, Keith ; Smith, Peter ; Lawrence, Stephen B ; Whiting, Lynda ; McNatty, Kenneth P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b532t-d82428eea6ee5153144b8399f0dff0d8410b0b49a0360f9040f554e629c8be493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Animals</topic><topic>Antibodies - blood</topic><topic>Antigens - administration & dosage</topic><topic>Antigens - immunology</topic><topic>Antigens - metabolism</topic><topic>Bone Morphogenetic Protein 15 - administration & dosage</topic><topic>Bone Morphogenetic Protein 15 - immunology</topic><topic>Bone Morphogenetic Protein 15 - metabolism</topic><topic>Cattle - immunology</topic><topic>Cattle - metabolism</topic><topic>Female</topic><topic>Growth Differentiation Factor 9 - administration & dosage</topic><topic>Growth Differentiation Factor 9 - immunology</topic><topic>Growth Differentiation Factor 9 - metabolism</topic><topic>Immunization - veterinary</topic><topic>Ovarian Follicle - immunology</topic><topic>Ovarian Follicle - metabolism</topic><topic>Ovary - immunology</topic><topic>Ovary - metabolism</topic><topic>Ovulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juengel, Jennifer L</creatorcontrib><creatorcontrib>Hudson, Norma L</creatorcontrib><creatorcontrib>Berg, Martin</creatorcontrib><creatorcontrib>Hamel, Keith</creatorcontrib><creatorcontrib>Smith, Peter</creatorcontrib><creatorcontrib>Lawrence, Stephen B</creatorcontrib><creatorcontrib>Whiting, Lynda</creatorcontrib><creatorcontrib>McNatty, Kenneth P</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juengel, Jennifer L</au><au>Hudson, Norma L</au><au>Berg, Martin</au><au>Hamel, Keith</au><au>Smith, Peter</au><au>Lawrence, Stephen B</au><au>Whiting, Lynda</au><au>McNatty, Kenneth P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>138</volume><issue>1</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are essential for ovarian follicular growth in sheep, whereas only GDF9 is essential in mice suggesting that the roles of these oocyte-derived growth factors differ among species. At present, however, there is only limited information on the action of BMP15 and GDF9 in other species. Thus, the aim of this experiment was to determine the effect of neutralizing GDF9 and/or BMP15 in vivo on ovarian follicular development and ovulation rate in cattle through active immunization using the mature regions of the proteins or peptides from the N-terminal area of mature regions. Immunization with the BMP15 peptide, with or without GDF9 peptide, significantly altered (increased or decreased) ovulation rate. In some animals, there were no functional corpora lutea (CL), whereas in others up to four CL were observed. From morphometric examination of the ovaries, immunization with GDF9 and/or BMP15 reduced the level of ovarian follicular development as assessed by a reduced proportion of the ovarian section occupied by antral follicles. In addition, immunization against GDF9 and/or BMP15 peptides reduced follicular size to <25% of that in the controls. In conclusion, immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle. Thus, as has been observed in sheep, both GDF9 and BMP15 appear to be key regulators of normal follicular development and ovulation rate in cattle.</abstract><cop>England</cop><pub>BioScientifica</pub><pmid>19439562</pmid><doi>10.1530/REP-09-0009</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adjuvants, Immunologic - administration & dosage Animals Antibodies - blood Antigens - administration & dosage Antigens - immunology Antigens - metabolism Bone Morphogenetic Protein 15 - administration & dosage Bone Morphogenetic Protein 15 - immunology Bone Morphogenetic Protein 15 - metabolism Cattle - immunology Cattle - metabolism Female Growth Differentiation Factor 9 - administration & dosage Growth Differentiation Factor 9 - immunology Growth Differentiation Factor 9 - metabolism Immunization - veterinary Ovarian Follicle - immunology Ovarian Follicle - metabolism Ovary - immunology Ovary - metabolism Ovulation |
| title | Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle |
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