Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition

Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that HOSM-1 cells, an osteosarcoma cell line established from human mandible, expressed mRNA for osteoblastic markers, such as alkaline phosphatase, osteonectin, osteocalcin and parathyroid hormone receptor, thus exhibiting a...

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Veröffentlicht in:	Anti-cancer drugs 2003-06, Vol.14 (5), p.377-381
Hauptverfasser:	Narita, Motoshi, Murata, Taku, Shimizu, Kasumi, Sugiyama, Takeo, Nakagawa, Toshiyuki, Manganiello, Vincent C, Tagawa, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - genetics 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Antineoplastic Agents Bone Neoplasms - enzymology Bone Neoplasms - genetics Bone Neoplasms - pathology Cell Division - drug effects Cell Line, Tumor Cyclic Nucleotide Phosphodiesterases, Type 4 Humans Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Osteosarcoma - enzymology Osteosarcoma - genetics Osteosarcoma - pathology Phosphodiesterase Inhibitors - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - biosynthesis Rolipram - pharmacology
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