Effect of ursodeoxycholic acid treatment on the expression and function of multidrug resistance-associated protein 2 in rat intestine

Effect of ursodeoxycholic acid (UDCA) treatment on the expression and function of intestinal multidrug resistance-associated protein (Mrp) 2 was examined in rats. When rats were orally administered 0.5% UDCA solution for 6 days, mRNA and protein levels of Mrp2 in the intestine were increased about t...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2009-08, Vol.98 (8), p.2822-2831
Hauptverfasser:	Yumoto, Ryoko, Hamada, Shota, Okada, Kaori, Kato, Yuki, Ikehata, Mika, Nagai, Junya, Takano, Mikihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences DNP-SG Gene Expression Regulation - drug effects General pharmacology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - physiology intestine Jejunum - drug effects Jejunum - metabolism Male Medical sciences methotrexate Mrp2 Multidrug Resistance-Associated Proteins - biosynthesis Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - physiology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Wistar Treatment Outcome UDCA Ursodeoxycholic Acid - pharmacology
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