Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience
Purpose To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer. Methods Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2009-08, Vol.135 (8), p.1117-1123 |
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| creator | Hashimoto, Kenji Mayahara, Hiroshi Takashima, Atsuo Nakajima, Takako Eguchi Kato, Ken Hamaguchi, Tetsuya Ito, Yoshinori Yamada, Yasuhide Kagami, Yoshikazu Itami, Jun Shimada, Yasuhiro |
| description | Purpose To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer. Methods Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2-50 Gy) and 2.5 Gy (range 1.8-3 Gy). Results The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy₁₀ or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively. Conclusion Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events. |
| doi_str_mv | 10.1007/s00432-009-0553-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733360007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1769492651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-80630c2a786b49bc14d5f0647b0cefd6cfc15515d450921476dae1ffaea0992c3</originalsourceid><addsrcrecordid>eNp9kU1r3DAQhkVpaTZpf0AvrSiEnpyOJEte51ZCvyCQQJuzGMsjr4LX3kp2af59ZLw00ENP-phn3hnel7E3Ai4EQPUxAZRKFgB1AVqrAp6xjVh-hFL6OduAqEShpTAn7DSle8hvXcmX7ETUEnSl9IaFW-z7gFP4TTxiu9zGgU87inh44H6MfEf7McYddsRHz-chUiI3YdMT7zBNMTjucHAULznyFIYuF8KQpjDNE3H6c6AYKNdfsRce-0Svj-cZu_vy-efVt-L65uv3q0_XhStrmIotGAVOYrU1TVk3TpSt9mDKqgFHvjXOO6G10G2poZairEyLJLxHQqhr6dQZ-7DqHuL4a6Y02X1IjvoeBxrnZCullIFsXybf_0Pej3Mc8nJWZn9KbSrIkFghF8eUInl7iGGP8cEKsEsKdk3B5hTskoJdet4ehedmT-1Tx9H2DJwfAUwOex-zgSH95XJidWa3mZMrl3Jp6Cg-bfi_6e_WJo-jxS5m4bsfEoQCYbQAbdQjJmWo6g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220545670</pqid></control><display><type>article</type><title>Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hashimoto, Kenji ; Mayahara, Hiroshi ; Takashima, Atsuo ; Nakajima, Takako Eguchi ; Kato, Ken ; Hamaguchi, Tetsuya ; Ito, Yoshinori ; Yamada, Yasuhide ; Kagami, Yoshikazu ; Itami, Jun ; Shimada, Yasuhiro</creator><creatorcontrib>Hashimoto, Kenji ; Mayahara, Hiroshi ; Takashima, Atsuo ; Nakajima, Takako Eguchi ; Kato, Ken ; Hamaguchi, Tetsuya ; Ito, Yoshinori ; Yamada, Yasuhide ; Kagami, Yoshikazu ; Itami, Jun ; Shimada, Yasuhiro</creatorcontrib><description>Purpose To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer. Methods Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2-50 Gy) and 2.5 Gy (range 1.8-3 Gy). Results The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy₁₀ or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively. Conclusion Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-009-0553-0</identifier><identifier>PMID: 19205735</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Biological and medical sciences ; Cancer ; Cancer Research ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Hemorrhage - pathology ; Gastrointestinal Hemorrhage - radiotherapy ; Hematology ; Hemorrhage ; Hemostasis ; Humans ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Paper ; Palliative Care ; Pharmacology. Drug treatments ; Radiation therapy ; Radiotherapy Dosage ; Retrospective Studies ; Side effects ; Stomach ; Stomach Neoplasms - pathology ; Stomach Neoplasms - radiotherapy ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Tumors</subject><ispartof>Journal of cancer research and clinical oncology, 2009-08, Vol.135 (8), p.1117-1123</ispartof><rights>Springer-Verlag 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-80630c2a786b49bc14d5f0647b0cefd6cfc15515d450921476dae1ffaea0992c3</citedby><cites>FETCH-LOGICAL-c490t-80630c2a786b49bc14d5f0647b0cefd6cfc15515d450921476dae1ffaea0992c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-009-0553-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-009-0553-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21691928$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19205735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashimoto, Kenji</creatorcontrib><creatorcontrib>Mayahara, Hiroshi</creatorcontrib><creatorcontrib>Takashima, Atsuo</creatorcontrib><creatorcontrib>Nakajima, Takako Eguchi</creatorcontrib><creatorcontrib>Kato, Ken</creatorcontrib><creatorcontrib>Hamaguchi, Tetsuya</creatorcontrib><creatorcontrib>Ito, Yoshinori</creatorcontrib><creatorcontrib>Yamada, Yasuhide</creatorcontrib><creatorcontrib>Kagami, Yoshikazu</creatorcontrib><creatorcontrib>Itami, Jun</creatorcontrib><creatorcontrib>Shimada, Yasuhiro</creatorcontrib><title>Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer. Methods Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2-50 Gy) and 2.5 Gy (range 1.8-3 Gy). Results The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy₁₀ or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively. Conclusion Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Hemorrhage - pathology</subject><subject>Gastrointestinal Hemorrhage - radiotherapy</subject><subject>Hematology</subject><subject>Hemorrhage</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Palliative Care</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiation therapy</subject><subject>Radiotherapy Dosage</subject><subject>Retrospective Studies</subject><subject>Side effects</subject><subject>Stomach</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - radiotherapy</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal Hemorrhage - pathology</topic><topic>Gastrointestinal Hemorrhage - radiotherapy</topic><topic>Hematology</topic><topic>Hemorrhage</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Palliative Care</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiation therapy</topic><topic>Radiotherapy Dosage</topic><topic>Retrospective Studies</topic><topic>Side effects</topic><topic>Stomach</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - radiotherapy</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashimoto, Kenji</creatorcontrib><creatorcontrib>Mayahara, Hiroshi</creatorcontrib><creatorcontrib>Takashima, Atsuo</creatorcontrib><creatorcontrib>Nakajima, Takako Eguchi</creatorcontrib><creatorcontrib>Kato, Ken</creatorcontrib><creatorcontrib>Hamaguchi, Tetsuya</creatorcontrib><creatorcontrib>Ito, Yoshinori</creatorcontrib><creatorcontrib>Yamada, Yasuhide</creatorcontrib><creatorcontrib>Kagami, Yoshikazu</creatorcontrib><creatorcontrib>Itami, Jun</creatorcontrib><creatorcontrib>Shimada, Yasuhiro</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashimoto, Kenji</au><au>Mayahara, Hiroshi</au><au>Takashima, Atsuo</au><au>Nakajima, Takako Eguchi</au><au>Kato, Ken</au><au>Hamaguchi, Tetsuya</au><au>Ito, Yoshinori</au><au>Yamada, Yasuhide</au><au>Kagami, Yoshikazu</au><au>Itami, Jun</au><au>Shimada, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>135</volume><issue>8</issue><spage>1117</spage><epage>1123</epage><pages>1117-1123</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>Purpose To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer. Methods Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2-50 Gy) and 2.5 Gy (range 1.8-3 Gy). Results The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy₁₀ or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively. Conclusion Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>19205735</pmid><doi>10.1007/s00432-009-0553-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Antineoplastic agents Biological and medical sciences Cancer Cancer Research Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Hemorrhage - pathology Gastrointestinal Hemorrhage - radiotherapy Hematology Hemorrhage Hemostasis Humans Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Oncology Original Paper Palliative Care Pharmacology. Drug treatments Radiation therapy Radiotherapy Dosage Retrospective Studies Side effects Stomach Stomach Neoplasms - pathology Stomach Neoplasms - radiotherapy Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors |
| title | Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience |
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