Hypoxia Influences the Vascular Expansion and Differentiation of Embryonic Stem Cell Cultures Through the Temporal Expression of Vascular Endothelial Growth Factor Receptors in an ARNT‐Dependent Manner

Adaptive responses to low oxygen (O2) tension (hypoxia) are mediated by the heterodimeric transcription factor hypoxia inducible factor (HIF). When stabilized by hypoxia, bHLH‐PAS α‐ and β‐ (HIF‐1β or ARNT) HIF complex regulate the expression of multiple genes, including vascular endothelial growth...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2010-04, Vol.28 (4), p.799-809
Hauptverfasser:	Han, Yu, Kuang, Shu‐Zhen, Gomer, Alla, Ramirez‐Bergeron, Diana L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals ARNT Aryl Hydrocarbon Receptor Nuclear Translocator - deficiency Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism Cell Differentiation Cell Hypoxia Cell Proliferation Cells, Cultured Embryoid bodies Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Endothelial cells Flk‐1 Flt‐1 Gene Expression Regulation Hypoxia Hypoxia inducible factor Mice Mice, Knockout Neovascularization, Physiologic Receptors, Vascular Endothelial Growth Factor - metabolism Transcription, Genetic Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vasculogenesis
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