The effects of acute tryptophan depletion on mood in patients with Parkinson’s disease and the healthy elderly

Reduced serotonergic tone may be a compensatory adaptation to reduced dopaminergic activity in Parkinson’s disease (PD) and may result in vulnerability to depression. To test this hypothesis this study examined the effects of serotonin depletion, using the technique of acute tryptophan depletion (AT...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2010-04, Vol.24 (4), p.615-619
Hauptverfasser:	Mace, JL, Porter, RJ, Dalrymple-Alford, JC, Anderson, TJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Affect Age Factors Aged Antidepressants Antiparkinson Agents - therapeutic use Biological and medical sciences Cross-Over Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depression Depression - diagnosis Depression - etiology Depression - metabolism Depression - psychology Double-Blind Method Effects Emotions Humans Medical sciences Middle Aged Mood disorders Neurology Neuropharmacology Neurotransmitters Older people Organic mental disorders. Neuropsychology Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - psychology Parkinson's disease Pharmacology. Drug treatments Placebo Effect Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Serotonin - metabolism Severity of Illness Index Tryptophan - deficiency
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