Monocyte Expression of Adhesion Molecules during Low- and High-Flux Polysulfone Hemodialysis and the Effect of Atorvastatin Administration
Background/Aims: Aims of the present study are to examine the effects of atorvastatin administration and the influence of membrane flux on adhesion molecules expression on monocytes. Methods: We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LF...
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| Veröffentlicht in: | Blood purification 2010-01, Vol.29 (3), p.274-279 |
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| creator | Stavroulopoulos, Aristeidis Petras, Dimitrios Kakavas, Ioannis Agroyannis, Ioannis Stamatelou, Kyriaki Vyssoulis, Georgios Papadakis, Ioannis T. Stefanadis, Christodoulos |
| description | Background/Aims: Aims of the present study are to examine the effects of atorvastatin administration and the influence of membrane flux on adhesion molecules expression on monocytes. Methods: We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LFD) and 16 on high-flux (HFD) polysulfone hemodialysis, before and after dialysis and also after administration of atorvastatin 20 mg/day for 6 months. Results: After hemodialysis, expression of CD11b and CD18 increased and expression of CD62L decreased. After atorvastatin administration there was a decrease in pre-dialysis monocyte expression of CD11b and CD18, and an increase in the expression of CD62L compared to pre-dialysis baseline values. There were no statistically significant differences in expression of all three molecules between LFD and HFD groups. Conclusions: Polysulfone dialysis process activates monocytes irrespectively of the membrane flux. Atorvastatin use is associated with reduced monocyte activation. |
| doi_str_mv | 10.1159/000274462 |
| format | Article |
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Methods: We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LFD) and 16 on high-flux (HFD) polysulfone hemodialysis, before and after dialysis and also after administration of atorvastatin 20 mg/day for 6 months. Results: After hemodialysis, expression of CD11b and CD18 increased and expression of CD62L decreased. After atorvastatin administration there was a decrease in pre-dialysis monocyte expression of CD11b and CD18, and an increase in the expression of CD62L compared to pre-dialysis baseline values. There were no statistically significant differences in expression of all three molecules between LFD and HFD groups. Conclusions: Polysulfone dialysis process activates monocytes irrespectively of the membrane flux. Atorvastatin use is associated with reduced monocyte activation.</description><identifier>ISSN: 0253-5068</identifier><identifier>EISSN: 1421-9735</identifier><identifier>DOI: 10.1159/000274462</identifier><identifier>PMID: 20068293</identifier><identifier>CODEN: BLPUDO</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Atorvastatin Calcium ; Biological and medical sciences ; CD11b Antigen - biosynthesis ; CD18 Antigens - biosynthesis ; Cell Adhesion Molecules - biosynthesis ; Cross-Over Studies ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Heptanoic Acids - therapeutic use ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - metabolism ; Kidney Failure, Chronic - therapy ; L-Selectin - biosynthesis ; Male ; Medical sciences ; Middle Aged ; Monocytes - immunology ; Original Paper ; Polymers ; Pyrroles - therapeutic use ; Renal Dialysis - instrumentation ; Renal Dialysis - methods ; Sulfones</subject><ispartof>Blood purification, 2010-01, Vol.29 (3), p.274-279</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-d3503470dd5b0ef2d6a3f18afed3849a3118af34f98e095da3a42402282e85023</citedby><cites>FETCH-LOGICAL-c335t-d3503470dd5b0ef2d6a3f18afed3849a3118af34f98e095da3a42402282e85023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2428,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24403622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20068293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stavroulopoulos, Aristeidis</creatorcontrib><creatorcontrib>Petras, Dimitrios</creatorcontrib><creatorcontrib>Kakavas, Ioannis</creatorcontrib><creatorcontrib>Agroyannis, Ioannis</creatorcontrib><creatorcontrib>Stamatelou, Kyriaki</creatorcontrib><creatorcontrib>Vyssoulis, Georgios</creatorcontrib><creatorcontrib>Papadakis, Ioannis T.</creatorcontrib><creatorcontrib>Stefanadis, Christodoulos</creatorcontrib><title>Monocyte Expression of Adhesion Molecules during Low- and High-Flux Polysulfone Hemodialysis and the Effect of Atorvastatin Administration</title><title>Blood purification</title><addtitle>Blood Purif</addtitle><description>Background/Aims: Aims of the present study are to examine the effects of atorvastatin administration and the influence of membrane flux on adhesion molecules expression on monocytes. Methods: We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LFD) and 16 on high-flux (HFD) polysulfone hemodialysis, before and after dialysis and also after administration of atorvastatin 20 mg/day for 6 months. Results: After hemodialysis, expression of CD11b and CD18 increased and expression of CD62L decreased. After atorvastatin administration there was a decrease in pre-dialysis monocyte expression of CD11b and CD18, and an increase in the expression of CD62L compared to pre-dialysis baseline values. There were no statistically significant differences in expression of all three molecules between LFD and HFD groups. Conclusions: Polysulfone dialysis process activates monocytes irrespectively of the membrane flux. Atorvastatin use is associated with reduced monocyte activation.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Atorvastatin Calcium</subject><subject>Biological and medical sciences</subject><subject>CD11b Antigen - biosynthesis</subject><subject>CD18 Antigens - biosynthesis</subject><subject>Cell Adhesion Molecules - biosynthesis</subject><subject>Cross-Over Studies</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Heptanoic Acids - therapeutic use</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>L-Selectin - biosynthesis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monocytes - immunology</subject><subject>Original Paper</subject><subject>Polymers</subject><subject>Pyrroles - therapeutic use</subject><subject>Renal Dialysis - instrumentation</subject><subject>Renal Dialysis - methods</subject><subject>Sulfones</subject><issn>0253-5068</issn><issn>1421-9735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtuEzEYhS0EomlgwR4hbxDqYoqvc1lWVdtUSkUXsB6549-JwWMH21OaV-CpcS60q_-iT9-RDkIfKDmnVHZfCSGsEaJmr9CMCkarruHyNZoRJnklSd2eoNOUfhJCRS27t-iEkfJkHZ-hv3fBh2GbAV89bSKkZIPHweALvYb9fhccDJODhPUUrV_hZfhTYeU1XtjVurp20xO-D26bJmeCB7yAMWirysOmPZbXxW0MDHnvzSE-qpRVtr6EjNbblGO5gn-H3hjlErw_zjn6cX31_XJRLb_d3F5eLKuBc5krzSXhoiFaywcChulacUNbZUDzVnSK093BhelaIJ3UiivBBGGsZdBKwvgcfTl4NzH8niDlfrRpAOeUhzClvuElp5Glwzk6O5BDDClFMP0m2lHFbU9Jv2u-f26-sJ-O1ulhBP1M_q-6AJ-PgEqDciYqP9j0wglBeM12oo8H7peKK4gvwCHnH8dxlS4</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Stavroulopoulos, Aristeidis</creator><creator>Petras, Dimitrios</creator><creator>Kakavas, Ioannis</creator><creator>Agroyannis, Ioannis</creator><creator>Stamatelou, Kyriaki</creator><creator>Vyssoulis, Georgios</creator><creator>Papadakis, Ioannis T.</creator><creator>Stefanadis, Christodoulos</creator><general>Karger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Monocyte Expression of Adhesion Molecules during Low- and High-Flux Polysulfone Hemodialysis and the Effect of Atorvastatin Administration</title><author>Stavroulopoulos, Aristeidis ; Petras, Dimitrios ; Kakavas, Ioannis ; Agroyannis, Ioannis ; Stamatelou, Kyriaki ; Vyssoulis, Georgios ; Papadakis, Ioannis T. ; Stefanadis, Christodoulos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-d3503470dd5b0ef2d6a3f18afed3849a3118af34f98e095da3a42402282e85023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Atorvastatin Calcium</topic><topic>Biological and medical sciences</topic><topic>CD11b Antigen - biosynthesis</topic><topic>CD18 Antigens - biosynthesis</topic><topic>Cell Adhesion Molecules - biosynthesis</topic><topic>Cross-Over Studies</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Heptanoic Acids - therapeutic use</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>L-Selectin - biosynthesis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monocytes - immunology</topic><topic>Original Paper</topic><topic>Polymers</topic><topic>Pyrroles - therapeutic use</topic><topic>Renal Dialysis - instrumentation</topic><topic>Renal Dialysis - methods</topic><topic>Sulfones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stavroulopoulos, Aristeidis</creatorcontrib><creatorcontrib>Petras, Dimitrios</creatorcontrib><creatorcontrib>Kakavas, Ioannis</creatorcontrib><creatorcontrib>Agroyannis, Ioannis</creatorcontrib><creatorcontrib>Stamatelou, Kyriaki</creatorcontrib><creatorcontrib>Vyssoulis, Georgios</creatorcontrib><creatorcontrib>Papadakis, Ioannis T.</creatorcontrib><creatorcontrib>Stefanadis, Christodoulos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood purification</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stavroulopoulos, Aristeidis</au><au>Petras, Dimitrios</au><au>Kakavas, Ioannis</au><au>Agroyannis, Ioannis</au><au>Stamatelou, Kyriaki</au><au>Vyssoulis, Georgios</au><au>Papadakis, Ioannis T.</au><au>Stefanadis, Christodoulos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monocyte Expression of Adhesion Molecules during Low- and High-Flux Polysulfone Hemodialysis and the Effect of Atorvastatin Administration</atitle><jtitle>Blood purification</jtitle><addtitle>Blood Purif</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>29</volume><issue>3</issue><spage>274</spage><epage>279</epage><pages>274-279</pages><issn>0253-5068</issn><eissn>1421-9735</eissn><coden>BLPUDO</coden><abstract>Background/Aims: Aims of the present study are to examine the effects of atorvastatin administration and the influence of membrane flux on adhesion molecules expression on monocytes. Methods: We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LFD) and 16 on high-flux (HFD) polysulfone hemodialysis, before and after dialysis and also after administration of atorvastatin 20 mg/day for 6 months. Results: After hemodialysis, expression of CD11b and CD18 increased and expression of CD62L decreased. After atorvastatin administration there was a decrease in pre-dialysis monocyte expression of CD11b and CD18, and an increase in the expression of CD62L compared to pre-dialysis baseline values. There were no statistically significant differences in expression of all three molecules between LFD and HFD groups. Conclusions: Polysulfone dialysis process activates monocytes irrespectively of the membrane flux. Atorvastatin use is associated with reduced monocyte activation.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>20068293</pmid><doi>10.1159/000274462</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Atorvastatin Calcium Biological and medical sciences CD11b Antigen - biosynthesis CD18 Antigens - biosynthesis Cell Adhesion Molecules - biosynthesis Cross-Over Studies Emergency and intensive care: renal failure. Dialysis management Female Heptanoic Acids - therapeutic use Humans Intensive care medicine Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy L-Selectin - biosynthesis Male Medical sciences Middle Aged Monocytes - immunology Original Paper Polymers Pyrroles - therapeutic use Renal Dialysis - instrumentation Renal Dialysis - methods Sulfones |
| title | Monocyte Expression of Adhesion Molecules during Low- and High-Flux Polysulfone Hemodialysis and the Effect of Atorvastatin Administration |
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