Cardiac findings in leptospirosis
Background/aimIn leptospirosis, although cardiac involvement in the form of ECG changes and myocarditis is known, it is not considered to be significant. This study analysed cardiac changes in leptospirosis.MethodsTwenty-four hearts from patients who had died from leptospirosis were studied. Detaile...
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| Veröffentlicht in: | Journal of clinical pathology 2010-02, Vol.63 (2), p.119-123 |
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| creator | Shah, Kinjal Amonkar, Gayathri P Kamat, Rima N Deshpande, Jaya R |
| description | Background/aimIn leptospirosis, although cardiac involvement in the form of ECG changes and myocarditis is known, it is not considered to be significant. This study analysed cardiac changes in leptospirosis.MethodsTwenty-four hearts from patients who had died from leptospirosis were studied. Detailed gross and light microscopic examination was carried out.ResultsMyocarditis was noted in 96% of cases. Endocardial inflammation was seen in 50% of cases. This endocardial inflammation correlates with vasculitis, which is the principal pathogenetic mechanism of the disease.ConclusionsThere is definite cardiac involvement in leptospirosis, which even though not symptomatically evident, may add to the morbidity or be contributory to the mortality associated with the disease. In addition, a possibility of dilated cardiomyopathy as a delayed consequence of severe myocarditis remains, and may need evaluation. |
| doi_str_mv | 10.1136/jcp.2009.069575 |
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This study analysed cardiac changes in leptospirosis.MethodsTwenty-four hearts from patients who had died from leptospirosis were studied. Detailed gross and light microscopic examination was carried out.ResultsMyocarditis was noted in 96% of cases. Endocardial inflammation was seen in 50% of cases. This endocardial inflammation correlates with vasculitis, which is the principal pathogenetic mechanism of the disease.ConclusionsThere is definite cardiac involvement in leptospirosis, which even though not symptomatically evident, may add to the morbidity or be contributory to the mortality associated with the disease. In addition, a possibility of dilated cardiomyopathy as a delayed consequence of severe myocarditis remains, and may need evaluation.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2009.069575</identifier><identifier>PMID: 20154032</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adolescent ; Adult ; Aged ; Autopsy pathology ; Bacterial diseases ; Biological and medical sciences ; cardiovascular ; Child ; Child, Preschool ; Endocarditis - microbiology ; Endocarditis - pathology ; Heart Diseases - microbiology ; Hemorrhage - microbiology ; Human bacterial diseases ; Humans ; Infectious diseases ; Investigative techniques, diagnostic techniques (general aspects) ; leptospirosis ; Leptospirosis - diagnosis ; Leptospirosis - pathology ; Medical sciences ; Middle Aged ; Miscellaneous ; Myocarditis - diagnosis ; Myocarditis - microbiology ; Myocarditis - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pericarditis - microbiology ; Pericarditis - pathology ; Young Adult</subject><ispartof>Journal of clinical pathology, 2010-02, Vol.63 (2), p.119-123</ispartof><rights>2010, Published by the BMJ Publishing Group Limited For permission to use, (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited For permission to use, (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b427t-6d071ee1e07681221055a9152c9d1d52ff0b0df93b84a7f5cf9e894cf3cfd04b3</citedby><cites>FETCH-LOGICAL-b427t-6d071ee1e07681221055a9152c9d1d52ff0b0df93b84a7f5cf9e894cf3cfd04b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jcp.bmj.com/content/63/2/119.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jcp.bmj.com/content/63/2/119.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22374943$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20154032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Kinjal</creatorcontrib><creatorcontrib>Amonkar, Gayathri P</creatorcontrib><creatorcontrib>Kamat, Rima N</creatorcontrib><creatorcontrib>Deshpande, Jaya R</creatorcontrib><title>Cardiac findings in leptospirosis</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Background/aimIn leptospirosis, although cardiac involvement in the form of ECG changes and myocarditis is known, it is not considered to be significant. This study analysed cardiac changes in leptospirosis.MethodsTwenty-four hearts from patients who had died from leptospirosis were studied. Detailed gross and light microscopic examination was carried out.ResultsMyocarditis was noted in 96% of cases. Endocardial inflammation was seen in 50% of cases. This endocardial inflammation correlates with vasculitis, which is the principal pathogenetic mechanism of the disease.ConclusionsThere is definite cardiac involvement in leptospirosis, which even though not symptomatically evident, may add to the morbidity or be contributory to the mortality associated with the disease. In addition, a possibility of dilated cardiomyopathy as a delayed consequence of severe myocarditis remains, and may need evaluation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Autopsy pathology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>cardiovascular</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endocarditis - microbiology</subject><subject>Endocarditis - pathology</subject><subject>Heart Diseases - microbiology</subject><subject>Hemorrhage - microbiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>leptospirosis</subject><subject>Leptospirosis - diagnosis</subject><subject>Leptospirosis - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Myocarditis - diagnosis</subject><subject>Myocarditis - microbiology</subject><subject>Myocarditis - pathology</subject><subject>Pathology. 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Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Pericarditis - microbiology</topic><topic>Pericarditis - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Kinjal</creatorcontrib><creatorcontrib>Amonkar, Gayathri P</creatorcontrib><creatorcontrib>Kamat, Rima N</creatorcontrib><creatorcontrib>Deshpande, Jaya R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Kinjal</au><au>Amonkar, Gayathri P</au><au>Kamat, Rima N</au><au>Deshpande, Jaya R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac findings in leptospirosis</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>63</volume><issue>2</issue><spage>119</spage><epage>123</epage><pages>119-123</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Background/aimIn leptospirosis, although cardiac involvement in the form of ECG changes and myocarditis is known, it is not considered to be significant. This study analysed cardiac changes in leptospirosis.MethodsTwenty-four hearts from patients who had died from leptospirosis were studied. Detailed gross and light microscopic examination was carried out.ResultsMyocarditis was noted in 96% of cases. Endocardial inflammation was seen in 50% of cases. This endocardial inflammation correlates with vasculitis, which is the principal pathogenetic mechanism of the disease.ConclusionsThere is definite cardiac involvement in leptospirosis, which even though not symptomatically evident, may add to the morbidity or be contributory to the mortality associated with the disease. In addition, a possibility of dilated cardiomyopathy as a delayed consequence of severe myocarditis remains, and may need evaluation.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>20154032</pmid><doi>10.1136/jcp.2009.069575</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Autopsy pathology Bacterial diseases Biological and medical sciences cardiovascular Child Child, Preschool Endocarditis - microbiology Endocarditis - pathology Heart Diseases - microbiology Hemorrhage - microbiology Human bacterial diseases Humans Infectious diseases Investigative techniques, diagnostic techniques (general aspects) leptospirosis Leptospirosis - diagnosis Leptospirosis - pathology Medical sciences Middle Aged Miscellaneous Myocarditis - diagnosis Myocarditis - microbiology Myocarditis - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pericarditis - microbiology Pericarditis - pathology Young Adult |
| title | Cardiac findings in leptospirosis |
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