Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer

We review here the recently emerging relationship between epithelial-mesenchymal transition (EMT) and breast cancer stem cells (BCSC), and provide analyses of published data on human breast cancer cell lines, supporting their utility as a model for the EMT/BCSC state. Genome-wide transcriptional pro...

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Veröffentlicht in:	Journal of mammary gland biology and neoplasia 2010-06, Vol.15 (2), p.235-252
Hauptverfasser:	Blick, Tony, Hugo, Honor, Widodo, Edwin, Waltham, Mark, Pinto, Cletus, Mani, Sendurai A, Weinberg, Robert A, Neve, Richard M, Lenburg, Marc E, Thompson, Erik W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - physiopathology CD24 Antigen - metabolism Cell Dedifferentiation Cell Line, Tumor Cell Transdifferentiation Epithelial Cells - physiology Female Humans Hyaluronan Receptors - metabolism Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - physiology Phenotype
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