Assessment of visual function after corneal transplantation: the quality of life and psychometric assessment after corneal transplantation (Q-PACT) study
Many patients with successful corneal grafts have poor vision postoperatively. This study evaluates changes in vision-related quality of life after penetrating keratoplasty (PK). Multicenter prospective cohort study. Penetrating keratoplasty candidates from the university-affiliated ophthalmology cl...
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| Veröffentlicht in: | American journal of ophthalmology 2003-06, Vol.135 (6), p.785-793 |
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| creator | Mendes, Flavia Schaumberg, Debra A Navon, Sam Steinert, Roger Sugar, Joel Holland, Edward J Dana, M.Reza |
| description | Many patients with successful corneal grafts have poor vision postoperatively. This study evaluates changes in vision-related quality of life after penetrating keratoplasty (PK).
Multicenter prospective cohort study.
Penetrating keratoplasty candidates from the university-affiliated ophthalmology clinics of four participating centers were enrolled and followed up prospectively. We used the PK-VFQ, a modified version of the Visual Function Index-14, combined with clinical examinations before and at 6 and 12 months after PK. We used multivariate linear regression models to examine predictors of change in PK-VFQ scores.
We studied 74 grafts in 71 eyes of 67 patients aged 23 to 91 (mean, 61) years who were followed up for at least 6 months. Indications for surgery included bullous keratopathy (27%), scarring (16%), keratoconus (16%), dystrophies (16%), and regrafts (15%). Median preoperative visual acuity was 20/200 in the graft candidate and 20/30 in the best eye. Median best-corrected postoperative visual acuity in the operated eyes was 20/60 at 6 months. PK-VFQ scores improved at 6 months in 79% by an average of 13.0 points (range, −16.7 to 67.5). Improvement in PK-VFQ scores was associated with younger age (
P = .04), poorer preoperative visual acuity in the best eye (
P = .001), and postoperative contact lens use (
P = .04) but not with postoperative acuity in the grafted eye (
P = .49). Postoperatively, 80% of patients were moderately to very satisfied with their vision, and 97% of patients stated they would have the surgery again.
Improvement in visual function is inversely associated with visual acuity in the better-seeing eye but does not correlate with the postoperative acuity in the grafted eye. Although most keratoplasties are done unilaterally in the setting of good visual acuity in the contralateral eye, for the majority of patients visual function improves after PK. |
| doi_str_mv | 10.1016/S0002-9394(02)02278-X |
| format | Article |
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Multicenter prospective cohort study.
Penetrating keratoplasty candidates from the university-affiliated ophthalmology clinics of four participating centers were enrolled and followed up prospectively. We used the PK-VFQ, a modified version of the Visual Function Index-14, combined with clinical examinations before and at 6 and 12 months after PK. We used multivariate linear regression models to examine predictors of change in PK-VFQ scores.
We studied 74 grafts in 71 eyes of 67 patients aged 23 to 91 (mean, 61) years who were followed up for at least 6 months. Indications for surgery included bullous keratopathy (27%), scarring (16%), keratoconus (16%), dystrophies (16%), and regrafts (15%). Median preoperative visual acuity was 20/200 in the graft candidate and 20/30 in the best eye. Median best-corrected postoperative visual acuity in the operated eyes was 20/60 at 6 months. PK-VFQ scores improved at 6 months in 79% by an average of 13.0 points (range, −16.7 to 67.5). Improvement in PK-VFQ scores was associated with younger age (
P = .04), poorer preoperative visual acuity in the best eye (
P = .001), and postoperative contact lens use (
P = .04) but not with postoperative acuity in the grafted eye (
P = .49). Postoperatively, 80% of patients were moderately to very satisfied with their vision, and 97% of patients stated they would have the surgery again.
Improvement in visual function is inversely associated with visual acuity in the better-seeing eye but does not correlate with the postoperative acuity in the grafted eye. Although most keratoplasties are done unilaterally in the setting of good visual acuity in the contralateral eye, for the majority of patients visual function improves after PK.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(02)02278-X</identifier><identifier>PMID: 12788117</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging ; Biological and medical sciences ; Colleges & universities ; Cornea - physiology ; Corneal Diseases - surgery ; Diseases of cornea, anterior segment and sclera ; Eyes & eyesight ; Female ; Follow-Up Studies ; Health Status Indicators ; Humans ; Keratoplasty, Penetrating - physiology ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Ophthalmology ; Outcome Assessment (Health Care) ; Patient Satisfaction ; Prospective Studies ; Psychometrics ; Quality of Life ; Questionnaires ; Standard deviation ; Success ; Surgery ; Surveys and Questionnaires ; Transplants & implants ; Visual Acuity - physiology ; Womens health</subject><ispartof>American journal of ophthalmology, 2003-06, Vol.135 (6), p.785-793</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-6b85d8543cf1d479a551abaf34fad5862ac43fc056cccccd3a453d7ef226599d3</citedby><cites>FETCH-LOGICAL-c514t-6b85d8543cf1d479a551abaf34fad5862ac43fc056cccccd3a453d7ef226599d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000293940202278X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14869070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12788117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mendes, Flavia</creatorcontrib><creatorcontrib>Schaumberg, Debra A</creatorcontrib><creatorcontrib>Navon, Sam</creatorcontrib><creatorcontrib>Steinert, Roger</creatorcontrib><creatorcontrib>Sugar, Joel</creatorcontrib><creatorcontrib>Holland, Edward J</creatorcontrib><creatorcontrib>Dana, M.Reza</creatorcontrib><title>Assessment of visual function after corneal transplantation: the quality of life and psychometric assessment after corneal transplantation (Q-PACT) study</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Many patients with successful corneal grafts have poor vision postoperatively. This study evaluates changes in vision-related quality of life after penetrating keratoplasty (PK).
Multicenter prospective cohort study.
Penetrating keratoplasty candidates from the university-affiliated ophthalmology clinics of four participating centers were enrolled and followed up prospectively. We used the PK-VFQ, a modified version of the Visual Function Index-14, combined with clinical examinations before and at 6 and 12 months after PK. We used multivariate linear regression models to examine predictors of change in PK-VFQ scores.
We studied 74 grafts in 71 eyes of 67 patients aged 23 to 91 (mean, 61) years who were followed up for at least 6 months. Indications for surgery included bullous keratopathy (27%), scarring (16%), keratoconus (16%), dystrophies (16%), and regrafts (15%). Median preoperative visual acuity was 20/200 in the graft candidate and 20/30 in the best eye. Median best-corrected postoperative visual acuity in the operated eyes was 20/60 at 6 months. PK-VFQ scores improved at 6 months in 79% by an average of 13.0 points (range, −16.7 to 67.5). Improvement in PK-VFQ scores was associated with younger age (
P = .04), poorer preoperative visual acuity in the best eye (
P = .001), and postoperative contact lens use (
P = .04) but not with postoperative acuity in the grafted eye (
P = .49). Postoperatively, 80% of patients were moderately to very satisfied with their vision, and 97% of patients stated they would have the surgery again.
Improvement in visual function is inversely associated with visual acuity in the better-seeing eye but does not correlate with the postoperative acuity in the grafted eye. Although most keratoplasties are done unilaterally in the setting of good visual acuity in the contralateral eye, for the majority of patients visual function improves after PK.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Colleges & universities</subject><subject>Cornea - physiology</subject><subject>Corneal Diseases - surgery</subject><subject>Diseases of cornea, anterior segment and sclera</subject><subject>Eyes & eyesight</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Keratoplasty, Penetrating - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Ophthalmology</subject><subject>Outcome Assessment (Health Care)</subject><subject>Patient Satisfaction</subject><subject>Prospective Studies</subject><subject>Psychometrics</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Standard deviation</subject><subject>Success</subject><subject>Surgery</subject><subject>Surveys and Questionnaires</subject><subject>Transplants & implants</subject><subject>Visual Acuity - physiology</subject><subject>Womens health</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9qFDEUxoModq0-ghIQpb0YTSbJJOONLIu1QkHFCr0L2eSEpsyfbZIp7KP4tma6Sxe8sLk5JPl93zmcD6HXlHyghDYffxFC6qplLT8h9Smpa6mqqydoQZVsK6pa-hQtHpAj9CKlm3JtJJfP0REttKJULtCfZUqQUg9DxqPHdyFNpsN-GmwO44CNzxCxHeMA5TlHM6RNZ4Zs5t9POF8Dvi2CkLezugsesBkc3qStvR57yDFYbA4d_muHT35WP5ary1Oc8uS2L9Ezb7oEr_b1GP0--3K5Oq8uvn_9tlpeVFZQnqtmrYRTgjPrqeOyNUJQszaecW-cUE1tLGfeEtHY-ThmuGBOgq_rRrStY8fo_c53E8fbCVLWfUgWujIXjFPSkjHGG6YK-PYf8Gac4lBm05TWirFGUlEosaNsHFOK4PUmht7EraZEz8np--T0HIsu9T45fVV0b_bu07oHd1DtoyrAuz1gkjWdL8uzIR04rpqWSFK4zzsOytLuAkSdbIDBggsRbNZuDI-M8hducLjj</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Mendes, Flavia</creator><creator>Schaumberg, Debra A</creator><creator>Navon, Sam</creator><creator>Steinert, Roger</creator><creator>Sugar, Joel</creator><creator>Holland, Edward J</creator><creator>Dana, M.Reza</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Assessment of visual function after corneal transplantation: the quality of life and psychometric assessment after corneal transplantation (Q-PACT) study</title><author>Mendes, Flavia ; Schaumberg, Debra A ; Navon, Sam ; Steinert, Roger ; Sugar, Joel ; Holland, Edward J ; Dana, M.Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-6b85d8543cf1d479a551abaf34fad5862ac43fc056cccccd3a453d7ef226599d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Colleges & universities</topic><topic>Cornea - physiology</topic><topic>Corneal Diseases - surgery</topic><topic>Diseases of cornea, anterior segment and sclera</topic><topic>Eyes & eyesight</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Keratoplasty, Penetrating - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Ophthalmology</topic><topic>Outcome Assessment (Health Care)</topic><topic>Patient Satisfaction</topic><topic>Prospective Studies</topic><topic>Psychometrics</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Standard deviation</topic><topic>Success</topic><topic>Surgery</topic><topic>Surveys and Questionnaires</topic><topic>Transplants & implants</topic><topic>Visual Acuity - physiology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mendes, Flavia</creatorcontrib><creatorcontrib>Schaumberg, Debra A</creatorcontrib><creatorcontrib>Navon, Sam</creatorcontrib><creatorcontrib>Steinert, Roger</creatorcontrib><creatorcontrib>Sugar, Joel</creatorcontrib><creatorcontrib>Holland, Edward J</creatorcontrib><creatorcontrib>Dana, M.Reza</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mendes, Flavia</au><au>Schaumberg, Debra A</au><au>Navon, Sam</au><au>Steinert, Roger</au><au>Sugar, Joel</au><au>Holland, Edward J</au><au>Dana, M.Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of visual function after corneal transplantation: the quality of life and psychometric assessment after corneal transplantation (Q-PACT) study</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>135</volume><issue>6</issue><spage>785</spage><epage>793</epage><pages>785-793</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Many patients with successful corneal grafts have poor vision postoperatively. This study evaluates changes in vision-related quality of life after penetrating keratoplasty (PK).
Multicenter prospective cohort study.
Penetrating keratoplasty candidates from the university-affiliated ophthalmology clinics of four participating centers were enrolled and followed up prospectively. We used the PK-VFQ, a modified version of the Visual Function Index-14, combined with clinical examinations before and at 6 and 12 months after PK. We used multivariate linear regression models to examine predictors of change in PK-VFQ scores.
We studied 74 grafts in 71 eyes of 67 patients aged 23 to 91 (mean, 61) years who were followed up for at least 6 months. Indications for surgery included bullous keratopathy (27%), scarring (16%), keratoconus (16%), dystrophies (16%), and regrafts (15%). Median preoperative visual acuity was 20/200 in the graft candidate and 20/30 in the best eye. Median best-corrected postoperative visual acuity in the operated eyes was 20/60 at 6 months. PK-VFQ scores improved at 6 months in 79% by an average of 13.0 points (range, −16.7 to 67.5). Improvement in PK-VFQ scores was associated with younger age (
P = .04), poorer preoperative visual acuity in the best eye (
P = .001), and postoperative contact lens use (
P = .04) but not with postoperative acuity in the grafted eye (
P = .49). Postoperatively, 80% of patients were moderately to very satisfied with their vision, and 97% of patients stated they would have the surgery again.
Improvement in visual function is inversely associated with visual acuity in the better-seeing eye but does not correlate with the postoperative acuity in the grafted eye. Although most keratoplasties are done unilaterally in the setting of good visual acuity in the contralateral eye, for the majority of patients visual function improves after PK.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12788117</pmid><doi>10.1016/S0002-9394(02)02278-X</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aging Biological and medical sciences Colleges & universities Cornea - physiology Corneal Diseases - surgery Diseases of cornea, anterior segment and sclera Eyes & eyesight Female Follow-Up Studies Health Status Indicators Humans Keratoplasty, Penetrating - physiology Male Medical sciences Middle Aged Multivariate Analysis Ophthalmology Outcome Assessment (Health Care) Patient Satisfaction Prospective Studies Psychometrics Quality of Life Questionnaires Standard deviation Success Surgery Surveys and Questionnaires Transplants & implants Visual Acuity - physiology Womens health |
| title | Assessment of visual function after corneal transplantation: the quality of life and psychometric assessment after corneal transplantation (Q-PACT) study |
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