Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo

We previously reported that adrenomedullin (AM), a vasodilating hormone secreted from blood vessels, promotes proliferation and migration of human umbilical vein endothelial cells (HUVECs). In this study, we examined the ability of AM to promote vascular regeneration. AM increased the phosphorylatio...

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Veröffentlicht in:	FEBS letters 2003-06, Vol.544 (1), p.86-92
Hauptverfasser:	Miyashita, Kazutoshi, Itoh, Hiroshi, Sawada, Naoki, Fukunaga, Yasutomo, Sone, Masakatsu, Yamahara, Kenichi, Yurugi-Kobayashi, Takami, Park, Kwijun, Nakao, Kazuwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Akt AM, adrenomedullin Angiogenesis Animals Biocompatible Materials - pharmacology Blotting, Western cAMP Cell Division Cell Movement Cells, Cultured Collagen - pharmacology Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Drug Drug Combinations Endothelium - physiology Endothelium, Vascular - cytology Enzyme Activation FBS, fetal bovine serum Humans HUVEC, human umbilical vein endothelial cell Laminin - pharmacology Mice Neovascularization, Physiologic NP, natriuretic peptide Peptides - chemistry Peptides - metabolism Peptides - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation PI3K, phosphatidylinositol 3-kinase PKA Inh. Peptide, myristoylated protein kinase A inhibitor peptide sequence (14–22) cell-permeable PKA, protein kinase A Protein Binding Protein-Serine-Threonine Kinases Proteoglycans - pharmacology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Re-endothelialization Regeneration Time Factors Vascular regeneration Wound Healing
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