Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD40L from human platelets: Role of HSP27 phosphorylation via p44/p42 MAPK

Abstract Collagen plays a crucial role in hemostasis and thrombosis by activating platelets and reportedly induces the phosphorylation of heat shock protein (HSP) 27 in human platelets. However, the exact role of HSP27 phosphorylation in human platelets has not yet been clarified. In the present stu...

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Veröffentlicht in:	Thrombosis research 2010-07, Vol.126 (1), p.39-43
Hauptverfasser:	Kato, Hisaaki, Adachi, Seiji, Doi, Tomoaki, Matsushima-Nishiwaki, Rie, Minamitani, Chiho, Akamatsu, Shigeru, Enomoto, Yukiko, Tokuda, Haruhiko, Otsuka, Takanobu, Iwama, Toru, Kozawa, Osamu, Ogura, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT Biological and medical sciences Blood and lymphatic vessels Blood Platelets - drug effects Blood Platelets - metabolism Blood vessels and receptors Cardiology. Vascular system CD40 Ligand - metabolism CD40 Ligand - pharmacology collagen Collagen - metabolism Collagen - pharmacology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Flavonoids Fundamental and applied biological sciences. Psychology Hematology, Oncology and Palliative Medicine HSP27 HSP27 Heat-Shock Proteins Humans Medical sciences Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinase Kinases - pharmacology Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - pharmacology PDGF-AB Phosphorylation - drug effects platelet Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology release sCD40L Serotonin - metabolism Serotonin - pharmacology Vertebrates: cardiovascular system
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