MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells

Leptin, the LEP gene product, is produced in placenta where it has been found to be an important autocrine signal for trophoblastic growth during pregnancy. Thus, we have recently described the antiapoptotic and trophic effect of leptin on choriocarcinoma cell line JEG-3, stimulating DNA and protein...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-06, Vol.396 (4), p.956-960
Hauptverfasser:	Pérez-Pérez, Antonio, Gambino, Yésica, Maymó, Julieta, Goberna, Raimundo, Fabiani, Fernando, Varone, Cecilia, Sánchez-Margalet, Víctor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Cell Line, Tumor Eukaryotic Initiation Factor-4E - metabolism Female Humans Leptin Leptin - metabolism Leptin - pharmacology MAP Kinase Signaling System Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - metabolism Phosphorylation Placenta Pregnancy Protein Biosynthesis Protein synthesis Proto-Oncogene Proteins c-akt - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal transduction Translation Trophoblasts - metabolism
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