The reversible oral P2Y12 antagonist AZD6140 inhibits ADP-induced contractions in murine and human vasculature

Abstract Objectives The platelet ADP P2Y12 receptor which is a target for the antithrombotic drug clopidogrel is also distributed on vascular smooth muscle cells and stimulate contraction. This study investigates whether AZD6140, in contrast to clopidogrel, can inhibit ADP-mediated arterial contract...

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Veröffentlicht in:	International journal of cardiology 2010-07, Vol.142 (2), p.187-192
Hauptverfasser:	Högberg, Carl, Svensson, Helen, Gustafsson, Ronny, Eyjolfsson, Atli, Erlinge, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - administration & dosage Adenosine - analogs & derivatives Adenosine - therapeutic use Adenosine Diphosphate - antagonists & inhibitors Adenosine Diphosphate - physiology Administration, Oral Aged Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Biological and medical sciences Cardiology. Vascular system Cardiovascular Female Humans Male Mammary Arteries - drug effects Mammary Arteries - physiology Medical sciences Mice Receptors, Purinergic P2Y12 - metabolism Receptors, Purinergic P2Y12 - physiology Species Specificity Ticagrelor Vasoconstriction - drug effects Vasoconstriction - physiology Vasoconstrictor Agents - administration & dosage Vasoconstrictor Agents - therapeutic use
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