Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica
Objective To assess the responsiveness of ultrasound (US) inflammatory findings in the shoulder and hip of patients with polymyalgia rheumatica (PMR) who started treatment with corticosteroids. Methods Fifty-three patients with active PMR who started treatment with prednisone in six Spanish centres...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2010-05, Vol.69 (5), p.879-882 |
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| container_title | Annals of the rheumatic diseases |
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| creator | Jiménez-Palop, M Naredo, E Humbrado, L Medina, J Uson, J Francisco, F García-Yebenes, M J Garrido, J |
| description | Objective To assess the responsiveness of ultrasound (US) inflammatory findings in the shoulder and hip of patients with polymyalgia rheumatica (PMR) who started treatment with corticosteroids. Methods Fifty-three patients with active PMR who started treatment with prednisone in six Spanish centres were prospectively studied. The patients underwent clinical, laboratory and US assessment at baseline, 4 and 12 weeks. The US investigation consisted of detection and quantification of inflammatory findings in the shoulder and hip. The responsiveness of clinical, laboratory and US parameters was tested by the standardised response mean. Intraobserver and interobserver reliability between US investigators was assessed. Results At baseline, 34 patients (69%) had inflammation in at least one bilateral site. During the follow-up period, clinical, laboratory and US variables showed a parallel decrease. A significant decrease in US inflammatory parameters was found at week 4 (p |
| doi_str_mv | 10.1136/ard.2009.113555 |
| format | Article |
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Methods Fifty-three patients with active PMR who started treatment with prednisone in six Spanish centres were prospectively studied. The patients underwent clinical, laboratory and US assessment at baseline, 4 and 12 weeks. The US investigation consisted of detection and quantification of inflammatory findings in the shoulder and hip. The responsiveness of clinical, laboratory and US parameters was tested by the standardised response mean. Intraobserver and interobserver reliability between US investigators was assessed. Results At baseline, 34 patients (69%) had inflammation in at least one bilateral site. During the follow-up period, clinical, laboratory and US variables showed a parallel decrease. A significant decrease in US inflammatory parameters was found at week 4 (p<0.001). After 4 and 12 weeks of treatment with corticosteroids, US inflammatory findings showed similar or better sensitivity to change than clinical and laboratory markers of PMR activity. Intraobserver and interobserver intraclass correlation coefficients were 0.96 and 0.99, respectively (p<0.05). Conclusion US may be a responsive additional tool in monitoring the response to corticosteroids in patients with PMR in daily practice and multicentre trials.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2009.113555</identifier><identifier>PMID: 19773289</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Bursitis ; Bursitis - diagnostic imaging ; Disease ; Diseases of the osteoarticular system ; Drug Monitoring - methods ; Female ; Follow-Up Studies ; Glucocorticoids - therapeutic use ; Hip Joint - diagnostic imaging ; Humans ; Inflammation ; Inflammatory joint diseases ; Laboratories ; Male ; Medical sciences ; Middle Aged ; Pain ; Polymyalgia Rheumatica - diagnostic imaging ; Polymyalgia Rheumatica - drug therapy ; Prednisone - therapeutic use ; Prospective Studies ; Rheumatology ; Shoulder Joint - diagnostic imaging ; Software ; Studies ; Synovitis - diagnostic imaging ; Tenosynovitis - diagnostic imaging ; Ultrasonography</subject><ispartof>Annals of the rheumatic diseases, 2010-05, Vol.69 (5), p.879-882</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b493t-e3f913de22f4e2229e70d441e32324e84fc5b783cf75ace50901f7f09f2509cf3</citedby><cites>FETCH-LOGICAL-b493t-e3f913de22f4e2229e70d441e32324e84fc5b783cf75ace50901f7f09f2509cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/69/5/879.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/69/5/879.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,778,782,3185,23554,27907,27908,77351,77382</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22643289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19773289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiménez-Palop, M</creatorcontrib><creatorcontrib>Naredo, E</creatorcontrib><creatorcontrib>Humbrado, L</creatorcontrib><creatorcontrib>Medina, J</creatorcontrib><creatorcontrib>Uson, J</creatorcontrib><creatorcontrib>Francisco, F</creatorcontrib><creatorcontrib>García-Yebenes, M J</creatorcontrib><creatorcontrib>Garrido, J</creatorcontrib><title>Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Objective To assess the responsiveness of ultrasound (US) inflammatory findings in the shoulder and hip of patients with polymyalgia rheumatica (PMR) who started treatment with corticosteroids. Methods Fifty-three patients with active PMR who started treatment with prednisone in six Spanish centres were prospectively studied. The patients underwent clinical, laboratory and US assessment at baseline, 4 and 12 weeks. The US investigation consisted of detection and quantification of inflammatory findings in the shoulder and hip. The responsiveness of clinical, laboratory and US parameters was tested by the standardised response mean. Intraobserver and interobserver reliability between US investigators was assessed. Results At baseline, 34 patients (69%) had inflammation in at least one bilateral site. During the follow-up period, clinical, laboratory and US variables showed a parallel decrease. A significant decrease in US inflammatory parameters was found at week 4 (p<0.001). After 4 and 12 weeks of treatment with corticosteroids, US inflammatory findings showed similar or better sensitivity to change than clinical and laboratory markers of PMR activity. Intraobserver and interobserver intraclass correlation coefficients were 0.96 and 0.99, respectively (p<0.05). Conclusion US may be a responsive additional tool in monitoring the response to corticosteroids in patients with PMR in daily practice and multicentre trials.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Bursitis</subject><subject>Bursitis - diagnostic imaging</subject><subject>Disease</subject><subject>Diseases of the osteoarticular system</subject><subject>Drug Monitoring - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Hip Joint - diagnostic imaging</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory joint diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain</subject><subject>Polymyalgia Rheumatica - diagnostic imaging</subject><subject>Polymyalgia Rheumatica - drug therapy</subject><subject>Prednisone - therapeutic use</subject><subject>Prospective Studies</subject><subject>Rheumatology</subject><subject>Shoulder Joint - diagnostic imaging</subject><subject>Software</subject><subject>Studies</subject><subject>Synovitis - diagnostic imaging</subject><subject>Tenosynovitis - diagnostic imaging</subject><subject>Ultrasonography</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0M-L1DAUB_Agiju7evYmBZEFobsvP9o0Rxn8BcMK4nrwEjKZl5mMbdNNWnD-ezO0rODFHJI88snj8SXkFYUbSnl9a-LuhgGoc1VV1ROyoqJuSgY1PCUrAOClULW8IJcpHXMJDW2ekwuqpOSsUSuyuW_HaFLowz6a4eBt0YXejyH6fl8EV0RMQ-gTFmMoxgNmcyp8XwyhPXUn0-69KeIBp86M3poX5JkzbcKXy3lF7j9--L7-XG6-fvqyfr8pt0LxsUTuFOU7ZMyJvDGFEnZCUOSMM4GNcLbayoZbJytjsQIF1EkHyrF8t45fkeu57xDDw4Rp1J1PFtvW9BimpCXPq4aGZ_nmH3kMU-zzcJpKKZsaqKyyup2VjSGliE4P0XcmnjQFfc5Z55z1OWc955x_vF76TtsOd3_9EmwGbxdgkjWti6a3Pj06xmqxuHJ2Po34-_HdxF-6llxW-u7HWouf3-6Aw1qf_bvZb7vjf6f8Ay11oYM</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Jiménez-Palop, M</creator><creator>Naredo, E</creator><creator>Humbrado, L</creator><creator>Medina, J</creator><creator>Uson, J</creator><creator>Francisco, F</creator><creator>García-Yebenes, M J</creator><creator>Garrido, J</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica</title><author>Jiménez-Palop, M ; Naredo, E ; Humbrado, L ; Medina, J ; Uson, J ; Francisco, F ; García-Yebenes, M J ; Garrido, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b493t-e3f913de22f4e2229e70d441e32324e84fc5b783cf75ace50901f7f09f2509cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Bursitis</topic><topic>Bursitis - diagnostic imaging</topic><topic>Disease</topic><topic>Diseases of the osteoarticular system</topic><topic>Drug Monitoring - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Hip Joint - diagnostic imaging</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory joint diseases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain</topic><topic>Polymyalgia Rheumatica - diagnostic imaging</topic><topic>Polymyalgia Rheumatica - drug therapy</topic><topic>Prednisone - therapeutic use</topic><topic>Prospective Studies</topic><topic>Rheumatology</topic><topic>Shoulder Joint - diagnostic imaging</topic><topic>Software</topic><topic>Studies</topic><topic>Synovitis - diagnostic imaging</topic><topic>Tenosynovitis - diagnostic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiménez-Palop, M</creatorcontrib><creatorcontrib>Naredo, E</creatorcontrib><creatorcontrib>Humbrado, L</creatorcontrib><creatorcontrib>Medina, J</creatorcontrib><creatorcontrib>Uson, J</creatorcontrib><creatorcontrib>Francisco, F</creatorcontrib><creatorcontrib>García-Yebenes, M J</creatorcontrib><creatorcontrib>Garrido, J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiménez-Palop, M</au><au>Naredo, E</au><au>Humbrado, L</au><au>Medina, J</au><au>Uson, J</au><au>Francisco, F</au><au>García-Yebenes, M J</au><au>Garrido, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>69</volume><issue>5</issue><spage>879</spage><epage>882</epage><pages>879-882</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Objective To assess the responsiveness of ultrasound (US) inflammatory findings in the shoulder and hip of patients with polymyalgia rheumatica (PMR) who started treatment with corticosteroids. Methods Fifty-three patients with active PMR who started treatment with prednisone in six Spanish centres were prospectively studied. The patients underwent clinical, laboratory and US assessment at baseline, 4 and 12 weeks. The US investigation consisted of detection and quantification of inflammatory findings in the shoulder and hip. The responsiveness of clinical, laboratory and US parameters was tested by the standardised response mean. Intraobserver and interobserver reliability between US investigators was assessed. Results At baseline, 34 patients (69%) had inflammation in at least one bilateral site. During the follow-up period, clinical, laboratory and US variables showed a parallel decrease. A significant decrease in US inflammatory parameters was found at week 4 (p<0.001). After 4 and 12 weeks of treatment with corticosteroids, US inflammatory findings showed similar or better sensitivity to change than clinical and laboratory markers of PMR activity. Intraobserver and interobserver intraclass correlation coefficients were 0.96 and 0.99, respectively (p<0.05). Conclusion US may be a responsive additional tool in monitoring the response to corticosteroids in patients with PMR in daily practice and multicentre trials.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>19773289</pmid><doi>10.1136/ard.2009.113555</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Bursitis Bursitis - diagnostic imaging Disease Diseases of the osteoarticular system Drug Monitoring - methods Female Follow-Up Studies Glucocorticoids - therapeutic use Hip Joint - diagnostic imaging Humans Inflammation Inflammatory joint diseases Laboratories Male Medical sciences Middle Aged Pain Polymyalgia Rheumatica - diagnostic imaging Polymyalgia Rheumatica - drug therapy Prednisone - therapeutic use Prospective Studies Rheumatology Shoulder Joint - diagnostic imaging Software Studies Synovitis - diagnostic imaging Tenosynovitis - diagnostic imaging Ultrasonography |
| title | Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica |
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