Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study

The chronic usage of nifedipine is associated with the appearance of gingival overgrowth (GO). The frequency of GO associated with chronic nifedipine therapy remains controversial and the possible subclinical effects of this drug on the gingival epithelium should be investigated. We investigated the...

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Veröffentlicht in:	Journal of Oral Science 2010, Vol.52(1), pp.55-62
Hauptverfasser:	Castro, Luciano A., Elias, Larissa S. A., Oton-Leite, Angélica F., Spíndula-Filho, José V. de, Leles, Claudio R., Batista, Aline C., Mendonça, Elismauro F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adverse effect Aged apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - analysis Calcium Channel Blockers - adverse effects Case-Control Studies cell proliferation Cell Proliferation - drug effects Cyclin B1 - analysis Dentistry Epithelial Cells - drug effects Epithelial Cells - pathology Female Gingiva - cytology Gingiva - drug effects gingival overgrowth Gingival Overgrowth - chemically induced Gingival Overgrowth - pathology Humans Immunohistochemistry Ki-67 Antigen - analysis Male Middle Aged nifedipine Nifedipine - adverse effects Proto-Oncogene Proteins c-bcl-2 - analysis Statistics, Nonparametric Tumor Suppressor Protein p53 - analysis
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