The expression of GST isoenzymes and p53 in non-small cell lung cancer
This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clin...
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| Veröffentlicht in: | Folia histochemica et cytobiologica 2010-01, Vol.48 (1), p.122-127 |
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| container_title | Folia histochemica et cytobiologica |
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| creator | Oguztüzun, Serpil Aydin, Mehtap Demirag, Funda Yazici, Ulkü Ozhavzali, Müzeyyen Kiliç, Murat Işcan, Mesude |
| description | This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alpha, theta and p53 was assessed by immunohistochemistry for primary lung carcinomas of 50 patients from the Sanitarium Education and Research Hospital, Ankara lung cancer collection. The relationships between expression of the glutathione-S-transferase isoenzymes, p53 in normal and tumor tissue by Student T test and the clinicopathological data were also examined by Spearman Rank tests. When the normal and tumor tissue of these cases were compared according to their staining intensity and percentage of positive staining, glutathione-S-transferase alpha, pi, mu, theta expressions in tumor cells was significantly higher than normal cells (p0.05). When the immunohistochemical results of glutathione-S-transferase isoenzymes and p53 were correlated with the clinical parameters, there were no significant associations between glutathione-S-transferases and p53 expressions and tumor stage, tumor grade and smoking status (p>0.05). |
| doi_str_mv | 10.2478/v10042-008-0084-6 |
| format | Article |
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The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alpha, theta and p53 was assessed by immunohistochemistry for primary lung carcinomas of 50 patients from the Sanitarium Education and Research Hospital, Ankara lung cancer collection. The relationships between expression of the glutathione-S-transferase isoenzymes, p53 in normal and tumor tissue by Student T test and the clinicopathological data were also examined by Spearman Rank tests. When the normal and tumor tissue of these cases were compared according to their staining intensity and percentage of positive staining, glutathione-S-transferase alpha, pi, mu, theta expressions in tumor cells was significantly higher than normal cells (p<0.05). There was no significant difference in the expression of p53 between normal and tumor cells (p>0.05). When the immunohistochemical results of glutathione-S-transferase isoenzymes and p53 were correlated with the clinical parameters, there were no significant associations between glutathione-S-transferases and p53 expressions and tumor stage, tumor grade and smoking status (p>0.05).</description><identifier>ISSN: 0239-8508</identifier><identifier>EISSN: 1897-5631</identifier><identifier>DOI: 10.2478/v10042-008-0084-6</identifier><identifier>PMID: 20529827</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Adenocarcinoma - enzymology ; Adenocarcinoma - pathology ; Carcinoma, Non-Small-Cell Lung - enzymology ; Carcinoma, Non-Small-Cell Lung - pathology ; Epithelium - enzymology ; Epithelium - pathology ; Glutathione ; Glutathione S-Transferase pi - metabolism ; Glutathione transferase ; Glutathione Transferase - metabolism ; Humans ; Immunohistochemistry ; Isoenzymes ; Isoenzymes - metabolism ; Lung cancer ; Lung carcinoma ; Lung Neoplasms - enzymology ; Lung Neoplasms - pathology ; Non-small cell lung carcinoma ; p53 Protein ; Patients ; Rank tests ; Small cell lung carcinoma ; Staining ; Tissues ; Tumor cells ; Tumor Suppressor Protein p53 - metabolism ; Tumors</subject><ispartof>Folia histochemica et cytobiologica, 2010-01, Vol.48 (1), p.122-127</ispartof><rights>2010. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright Folia Histochemica et Cytobiologica 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-d691cf1a9e68e856e992207ccdb8ce2a6af66067687b10c7c842f4f755fd0da63</citedby><cites>FETCH-LOGICAL-c464t-d691cf1a9e68e856e992207ccdb8ce2a6af66067687b10c7c842f4f755fd0da63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20529827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oguztüzun, Serpil</creatorcontrib><creatorcontrib>Aydin, Mehtap</creatorcontrib><creatorcontrib>Demirag, Funda</creatorcontrib><creatorcontrib>Yazici, Ulkü</creatorcontrib><creatorcontrib>Ozhavzali, Müzeyyen</creatorcontrib><creatorcontrib>Kiliç, Murat</creatorcontrib><creatorcontrib>Işcan, Mesude</creatorcontrib><title>The expression of GST isoenzymes and p53 in non-small cell lung cancer</title><title>Folia histochemica et cytobiologica</title><addtitle>Folia Histochem Cytobiol</addtitle><description>This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alpha, theta and p53 was assessed by immunohistochemistry for primary lung carcinomas of 50 patients from the Sanitarium Education and Research Hospital, Ankara lung cancer collection. The relationships between expression of the glutathione-S-transferase isoenzymes, p53 in normal and tumor tissue by Student T test and the clinicopathological data were also examined by Spearman Rank tests. When the normal and tumor tissue of these cases were compared according to their staining intensity and percentage of positive staining, glutathione-S-transferase alpha, pi, mu, theta expressions in tumor cells was significantly higher than normal cells (p<0.05). There was no significant difference in the expression of p53 between normal and tumor cells (p>0.05). When the immunohistochemical results of glutathione-S-transferase isoenzymes and p53 were correlated with the clinical parameters, there were no significant associations between glutathione-S-transferases and p53 expressions and tumor stage, tumor grade and smoking status (p>0.05).</description><subject>Adenocarcinoma - enzymology</subject><subject>Adenocarcinoma - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - enzymology</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Epithelium - enzymology</subject><subject>Epithelium - pathology</subject><subject>Glutathione</subject><subject>Glutathione S-Transferase pi - metabolism</subject><subject>Glutathione transferase</subject><subject>Glutathione Transferase - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Isoenzymes</subject><subject>Isoenzymes - metabolism</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lung Neoplasms - enzymology</subject><subject>Lung Neoplasms - pathology</subject><subject>Non-small cell lung carcinoma</subject><subject>p53 Protein</subject><subject>Patients</subject><subject>Rank tests</subject><subject>Small cell lung carcinoma</subject><subject>Staining</subject><subject>Tissues</subject><subject>Tumor cells</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><issn>0239-8508</issn><issn>1897-5631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU9Lw0AQxRdRbK1-AC-y6MFTdPb_5ijFVqHgwXpetpuNpiSbmG3E-ulNaPUgOPBmLr8ZHvMQOidwQ7nStx8EgNMEQA_iiTxAY6JTlQjJyCEaA2VpogXoETqJcQ0gJHByjEYUBE01VWM0W7557D-b1sdY1AHXOZ4_L3ERax--tpWP2IYMN4LhIuBQhyRWtiyx830ru_CKnQ3Ot6foKLdl9Gf7OUEvs_vl9CFZPM0fp3eLxHHJN0kmU-JyYlMvtddC-jSlFJRz2Uo7T620uZQgldRqRcAppznNea6EyDPIrGQTdL2727T1e-fjxlRFHMzY4OsuGsX6EoyRnrz8Q67rrg29OSOo0oRJYD109R9EZUo1SE5oT5Ed5do6xtbnpmmLyrZbQ8AMQZhdEKYPYRA3g9GL_eVuVfnsd-Pn8-wbjsiAng</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Oguztüzun, Serpil</creator><creator>Aydin, Mehtap</creator><creator>Demirag, Funda</creator><creator>Yazici, Ulkü</creator><creator>Ozhavzali, Müzeyyen</creator><creator>Kiliç, Murat</creator><creator>Işcan, Mesude</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>The expression of GST isoenzymes and p53 in non-small cell lung cancer</title><author>Oguztüzun, Serpil ; Aydin, Mehtap ; Demirag, Funda ; Yazici, Ulkü ; Ozhavzali, Müzeyyen ; Kiliç, Murat ; Işcan, Mesude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-d691cf1a9e68e856e992207ccdb8ce2a6af66067687b10c7c842f4f755fd0da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - 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Academic</collection><jtitle>Folia histochemica et cytobiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oguztüzun, Serpil</au><au>Aydin, Mehtap</au><au>Demirag, Funda</au><au>Yazici, Ulkü</au><au>Ozhavzali, Müzeyyen</au><au>Kiliç, Murat</au><au>Işcan, Mesude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The expression of GST isoenzymes and p53 in non-small cell lung cancer</atitle><jtitle>Folia histochemica et cytobiologica</jtitle><addtitle>Folia Histochem Cytobiol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>48</volume><issue>1</issue><spage>122</spage><epage>127</epage><pages>122-127</pages><issn>0239-8508</issn><eissn>1897-5631</eissn><abstract>This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alpha, theta and p53 was assessed by immunohistochemistry for primary lung carcinomas of 50 patients from the Sanitarium Education and Research Hospital, Ankara lung cancer collection. The relationships between expression of the glutathione-S-transferase isoenzymes, p53 in normal and tumor tissue by Student T test and the clinicopathological data were also examined by Spearman Rank tests. When the normal and tumor tissue of these cases were compared according to their staining intensity and percentage of positive staining, glutathione-S-transferase alpha, pi, mu, theta expressions in tumor cells was significantly higher than normal cells (p<0.05). There was no significant difference in the expression of p53 between normal and tumor cells (p>0.05). When the immunohistochemical results of glutathione-S-transferase isoenzymes and p53 were correlated with the clinical parameters, there were no significant associations between glutathione-S-transferases and p53 expressions and tumor stage, tumor grade and smoking status (p>0.05).</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>20529827</pmid><doi>10.2478/v10042-008-0084-6</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - enzymology Adenocarcinoma - pathology Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Epithelium - enzymology Epithelium - pathology Glutathione Glutathione S-Transferase pi - metabolism Glutathione transferase Glutathione Transferase - metabolism Humans Immunohistochemistry Isoenzymes Isoenzymes - metabolism Lung cancer Lung carcinoma Lung Neoplasms - enzymology Lung Neoplasms - pathology Non-small cell lung carcinoma p53 Protein Patients Rank tests Small cell lung carcinoma Staining Tissues Tumor cells Tumor Suppressor Protein p53 - metabolism Tumors |
| title | The expression of GST isoenzymes and p53 in non-small cell lung cancer |
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