Green hydrophilic interaction chromatography using ethanol-water-carbon dioxide mixtures
In hydrophilic interaction chromatography (HILIC), best results are obtained with high concentrations of acetonitrile. In the framework of green chromatography, different concentrations of carbon dioxide were added to the mobile phases acetonitrile-water and ethanol-water and the impact on retention...
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| Veröffentlicht in: | Journal of separation science 2010-03, Vol.33 (6-7), p.834-837 |
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| container_issue | 6-7 |
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| container_title | Journal of separation science |
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| creator | dos Santos Pereira, Alberto Girón, Ana Jiménez Admasu, Engdawork Sandra, Pat |
| description | In hydrophilic interaction chromatography (HILIC), best results are obtained with high concentrations of acetonitrile. In the framework of green chromatography, different concentrations of carbon dioxide were added to the mobile phases acetonitrile-water and ethanol-water and the impact on retention and separation in HILIC using bare silica as stationary phase was explored. The features of HILIC using enhanced-fluidity mobile phases are illustrated with the analysis of the nucleobases and a mixture containing the nucleobases and cortisol, flurbiprofen, theophylline and caffeine. For both organic constituents, the elution window is widened in function of the carbon dioxide concentration and selectivity changes. At high concentrations of carbon dioxide in ethanol, separations were similar to those obtained with acetonitrile without carbon dioxide addition. |
| doi_str_mv | 10.1002/jssc.200900791 |
| format | Article |
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In the framework of green chromatography, different concentrations of carbon dioxide were added to the mobile phases acetonitrile-water and ethanol-water and the impact on retention and separation in HILIC using bare silica as stationary phase was explored. The features of HILIC using enhanced-fluidity mobile phases are illustrated with the analysis of the nucleobases and a mixture containing the nucleobases and cortisol, flurbiprofen, theophylline and caffeine. For both organic constituents, the elution window is widened in function of the carbon dioxide concentration and selectivity changes. 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At high concentrations of carbon dioxide in ethanol, separations were similar to those obtained with acetonitrile without carbon dioxide addition.</description><subject>Acetonitrile</subject><subject>Bare silica</subject><subject>Carbon dioxide</subject><subject>Carbon Dioxide - chemistry</subject><subject>Carbon dioxide concentration</subject><subject>Chromatography</subject><subject>Chromatography, Liquid - methods</subject><subject>Enhanced-fluidity mobile phases</subject><subject>Ethanol</subject><subject>Ethanol - chemistry</subject><subject>Ethyl alcohol</subject><subject>Green chromatography</subject><subject>Hydrophilic interaction chromatography</subject><subject>Phases</subject><subject>Separation</subject><subject>Water - chemistry</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0L2P0zAYBnALgbgPWBkhGywpr51Pj6iCAqpg6J3oZtnO68ZHEvfsRNf-9-cqR8UEXuzh9zyyHkLeUFhQAPbxLgS9YAAcoOL0GbmkJS1SntH8-fkN5QW5CuEOgFY1h5fkggFjLAYuyXblEYekPTbe7VvbWZ3YYUQv9WjdkOjWu16Obuflvj0mU7DDLsGxlYPr0gcZYaqlV1E21h1sg0lvD-PkMbwiL4zsAr5-uq_J7ZfPN8uv6frn6tvy0zrVecZpalihleZS1UYC6gygMbWhtFDx3wXyqi4LphQWUiJTLC-NxJxSJhXNDW-q7Jq8n3v33t1PGEbR26Cx6-SAbgqiyuLJY02UH_4pKSvLKqs48EgXM9XeheDRiL23vfRHQUGcdhen3cV59xh4-9Q9qR6bM_8zdAR8Bg-2w-N_6sT3zWb5d3k6Z20Y8XDOSv9bnD5ciF8_VmINy4LdFFuxjf7d7I10Qu68DeJ2w4BmQGtWMsizR1vvqZs</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>dos Santos Pereira, Alberto</creator><creator>Girón, Ana Jiménez</creator><creator>Admasu, Engdawork</creator><creator>Sandra, Pat</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201003</creationdate><title>Green hydrophilic interaction chromatography using ethanol-water-carbon dioxide mixtures</title><author>dos Santos Pereira, Alberto ; Girón, Ana Jiménez ; Admasu, Engdawork ; Sandra, Pat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4391-f25cbc9ab8fa0ec300df8f115b9305e978652bbe5aae2b246fae4112ab14f9d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acetonitrile</topic><topic>Bare silica</topic><topic>Carbon dioxide</topic><topic>Carbon Dioxide - chemistry</topic><topic>Carbon dioxide concentration</topic><topic>Chromatography</topic><topic>Chromatography, Liquid - methods</topic><topic>Enhanced-fluidity mobile phases</topic><topic>Ethanol</topic><topic>Ethanol - chemistry</topic><topic>Ethyl alcohol</topic><topic>Green chromatography</topic><topic>Hydrophilic interaction chromatography</topic><topic>Phases</topic><topic>Separation</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>dos Santos Pereira, Alberto</creatorcontrib><creatorcontrib>Girón, Ana Jiménez</creatorcontrib><creatorcontrib>Admasu, Engdawork</creatorcontrib><creatorcontrib>Sandra, Pat</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>dos Santos Pereira, Alberto</au><au>Girón, Ana Jiménez</au><au>Admasu, Engdawork</au><au>Sandra, Pat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green hydrophilic interaction chromatography using ethanol-water-carbon dioxide mixtures</atitle><jtitle>Journal of separation science</jtitle><addtitle>J. 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| identifier | ISSN: 1615-9306 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Acetonitrile Bare silica Carbon dioxide Carbon Dioxide - chemistry Carbon dioxide concentration Chromatography Chromatography, Liquid - methods Enhanced-fluidity mobile phases Ethanol Ethanol - chemistry Ethyl alcohol Green chromatography Hydrophilic interaction chromatography Phases Separation Water - chemistry |
| title | Green hydrophilic interaction chromatography using ethanol-water-carbon dioxide mixtures |
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