Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother–newborn pairs
In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential intera...
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| Veröffentlicht in: | Environment international 2010-05, Vol.36 (4), p.344-351 |
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| creator | Pedersen, Marie Halldorsson, Thorhallur I. Mathiesen, Line Mose, Tina Brouwer, Abraham Hedegaard, Morten Loft, Steffen Kleinjans, Jos C.S. Besselink, Harrie Knudsen, Lisbeth E. |
| description | In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)® bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX®-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX®-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother–newborns (0.10 versus 0.18ng CALUX®-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX®-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P |
| doi_str_mv | 10.1016/j.envint.2010.02.002 |
| format | Article |
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Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)® bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX®-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX®-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother–newborns (0.10 versus 0.18ng CALUX®-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX®-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P<0.001) whereas dioxin-like and estrogenic activities were modestly associated with maternal levels (Rs≤0.4, P<0.001). The micronuclei frequency, an indicator of genetic instability was significantly associated with dioxin-like activity in cord blood, independently of other recorded factors (Rs=0.4, P<0.003). This study demonstrated interactions in vivo between dioxin-like, estrogenic and androgenic exposures during fetal development of humans.</description><identifier>ISSN: 0160-4120</identifier><identifier>EISSN: 1873-6750</identifier><identifier>DOI: 10.1016/j.envint.2010.02.002</identifier><identifier>PMID: 20189248</identifier><identifier>CODEN: ENVIDV</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Androgens ; Androgens - toxicity ; Biological and medical sciences ; Biological Assay - methods ; CALUX ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dioxins ; Dioxins - toxicity ; Environmental Exposure ; Environmental Pollutants - toxicity ; Estrogens ; Estrogens - toxicity ; Female ; Gene Expression - drug effects ; Genes, Reporter ; Humans ; Infant, Newborn ; Luciferases - biosynthesis ; Luciferases - genetics ; Medical sciences ; Micronuclei ; Micronuclei, Chromosome-Defective - chemically induced ; Mothers ; Placenta - chemistry ; Plasma - chemistry ; Pregnancy ; Toxicology ; Transplacental transport ; Various organic compounds ; Young Adult</subject><ispartof>Environment international, 2010-05, Vol.36 (4), p.344-351</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-4dd95ba4df71a4a9cab2c426efdffc94fc3639e0659d40d0ff07fa5aedb614a3</citedby><cites>FETCH-LOGICAL-c391t-4dd95ba4df71a4a9cab2c426efdffc94fc3639e0659d40d0ff07fa5aedb614a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0160412010000231$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22636394$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20189248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedersen, Marie</creatorcontrib><creatorcontrib>Halldorsson, Thorhallur I.</creatorcontrib><creatorcontrib>Mathiesen, Line</creatorcontrib><creatorcontrib>Mose, Tina</creatorcontrib><creatorcontrib>Brouwer, Abraham</creatorcontrib><creatorcontrib>Hedegaard, Morten</creatorcontrib><creatorcontrib>Loft, Steffen</creatorcontrib><creatorcontrib>Kleinjans, Jos C.S.</creatorcontrib><creatorcontrib>Besselink, Harrie</creatorcontrib><creatorcontrib>Knudsen, Lisbeth E.</creatorcontrib><title>Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother–newborn pairs</title><title>Environment international</title><addtitle>Environ Int</addtitle><description>In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)® bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX®-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX®-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother–newborns (0.10 versus 0.18ng CALUX®-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX®-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P<0.001) whereas dioxin-like and estrogenic activities were modestly associated with maternal levels (Rs≤0.4, P<0.001). The micronuclei frequency, an indicator of genetic instability was significantly associated with dioxin-like activity in cord blood, independently of other recorded factors (Rs=0.4, P<0.003). This study demonstrated interactions in vivo between dioxin-like, estrogenic and androgenic exposures during fetal development of humans.</description><subject>Adult</subject><subject>Androgens</subject><subject>Androgens - toxicity</subject><subject>Biological and medical sciences</subject><subject>Biological Assay - methods</subject><subject>CALUX</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dioxins</subject><subject>Dioxins - toxicity</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - toxicity</subject><subject>Estrogens</subject><subject>Estrogens - toxicity</subject><subject>Female</subject><subject>Gene Expression - drug effects</subject><subject>Genes, Reporter</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Luciferases - biosynthesis</subject><subject>Luciferases - genetics</subject><subject>Medical sciences</subject><subject>Micronuclei</subject><subject>Micronuclei, Chromosome-Defective - chemically induced</subject><subject>Mothers</subject><subject>Placenta - chemistry</subject><subject>Plasma - chemistry</subject><subject>Pregnancy</subject><subject>Toxicology</subject><subject>Transplacental transport</subject><subject>Various organic compounds</subject><subject>Young Adult</subject><issn>0160-4120</issn><issn>1873-6750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFO3DAQhq2qqCzbvkGFfKk4ZbETJ9lckCoKLRISl71bjj0GbxN7sRMKEgfegTfkSTrb3QX1giXLY_v7xzO_CfnK2YwzXh0vZ-DvnB9mOcMjls8Yyz-QCZ_XRVbVJftIJoixTPCc7ZODlJYMCTEvP5F9lMwbjCfk8YcL985nnfsNFO5XIY0RElXeULAW9JBo8BTSEMM1eKf_3eDcbf-X9E7H4EfdgaM2wu0IXj9Q52kfhhuIL0_PHv60IXq6Ui6mz2TPqi7Bl-06JYvzs8Xpr-zy6ufF6ffLTBcNHzJhTFO2ShhbcyVUo1Wba5FXYI21uhFWF1XRAKvKxghmmLWstqpUYNqKC1VMydEm7SoGLCkNsndJQ9cpD2FMsi5wCIFJpkRsSGwjpQhWrqLrVXyQnMm163IpN67LteuS5RI9Rdnh9oGx7cG8inY2I_BtC6ikVWej8tqlNy6v1h0I5E42HKAbdw6iTNqhh2BcxL-QJrj3K_kL-ienmg</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Pedersen, Marie</creator><creator>Halldorsson, Thorhallur I.</creator><creator>Mathiesen, Line</creator><creator>Mose, Tina</creator><creator>Brouwer, Abraham</creator><creator>Hedegaard, Morten</creator><creator>Loft, Steffen</creator><creator>Kleinjans, Jos C.S.</creator><creator>Besselink, Harrie</creator><creator>Knudsen, Lisbeth E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother–newborn pairs</title><author>Pedersen, Marie ; Halldorsson, Thorhallur I. ; Mathiesen, Line ; Mose, Tina ; Brouwer, Abraham ; Hedegaard, Morten ; Loft, Steffen ; Kleinjans, Jos C.S. ; Besselink, Harrie ; Knudsen, Lisbeth E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-4dd95ba4df71a4a9cab2c426efdffc94fc3639e0659d40d0ff07fa5aedb614a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Androgens</topic><topic>Androgens - toxicity</topic><topic>Biological and medical sciences</topic><topic>Biological Assay - methods</topic><topic>CALUX</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Dioxins</topic><topic>Dioxins - toxicity</topic><topic>Environmental Exposure</topic><topic>Environmental Pollutants - toxicity</topic><topic>Estrogens</topic><topic>Estrogens - toxicity</topic><topic>Female</topic><topic>Gene Expression - drug effects</topic><topic>Genes, Reporter</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Luciferases - biosynthesis</topic><topic>Luciferases - genetics</topic><topic>Medical sciences</topic><topic>Micronuclei</topic><topic>Micronuclei, Chromosome-Defective - chemically induced</topic><topic>Mothers</topic><topic>Placenta - chemistry</topic><topic>Plasma - chemistry</topic><topic>Pregnancy</topic><topic>Toxicology</topic><topic>Transplacental transport</topic><topic>Various organic compounds</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedersen, Marie</creatorcontrib><creatorcontrib>Halldorsson, Thorhallur I.</creatorcontrib><creatorcontrib>Mathiesen, Line</creatorcontrib><creatorcontrib>Mose, Tina</creatorcontrib><creatorcontrib>Brouwer, Abraham</creatorcontrib><creatorcontrib>Hedegaard, Morten</creatorcontrib><creatorcontrib>Loft, Steffen</creatorcontrib><creatorcontrib>Kleinjans, Jos C.S.</creatorcontrib><creatorcontrib>Besselink, Harrie</creatorcontrib><creatorcontrib>Knudsen, Lisbeth E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environment international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedersen, Marie</au><au>Halldorsson, Thorhallur I.</au><au>Mathiesen, Line</au><au>Mose, Tina</au><au>Brouwer, Abraham</au><au>Hedegaard, Morten</au><au>Loft, Steffen</au><au>Kleinjans, Jos C.S.</au><au>Besselink, Harrie</au><au>Knudsen, Lisbeth E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother–newborn pairs</atitle><jtitle>Environment international</jtitle><addtitle>Environ Int</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>36</volume><issue>4</issue><spage>344</spage><epage>351</epage><pages>344-351</pages><issn>0160-4120</issn><eissn>1873-6750</eissn><coden>ENVIDV</coden><abstract>In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)® bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX®-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX®-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother–newborns (0.10 versus 0.18ng CALUX®-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX®-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P<0.001) whereas dioxin-like and estrogenic activities were modestly associated with maternal levels (Rs≤0.4, P<0.001). The micronuclei frequency, an indicator of genetic instability was significantly associated with dioxin-like activity in cord blood, independently of other recorded factors (Rs=0.4, P<0.003). This study demonstrated interactions in vivo between dioxin-like, estrogenic and androgenic exposures during fetal development of humans.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>20189248</pmid><doi>10.1016/j.envint.2010.02.002</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-4120 |
| ispartof | Environment international, 2010-05, Vol.36 (4), p.344-351 |
| issn | 0160-4120 1873-6750 |
| language | eng |
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| subjects | Adult Androgens Androgens - toxicity Biological and medical sciences Biological Assay - methods CALUX Chemical and industrial products toxicology. Toxic occupational diseases Dioxins Dioxins - toxicity Environmental Exposure Environmental Pollutants - toxicity Estrogens Estrogens - toxicity Female Gene Expression - drug effects Genes, Reporter Humans Infant, Newborn Luciferases - biosynthesis Luciferases - genetics Medical sciences Micronuclei Micronuclei, Chromosome-Defective - chemically induced Mothers Placenta - chemistry Plasma - chemistry Pregnancy Toxicology Transplacental transport Various organic compounds Young Adult |
| title | Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother–newborn pairs |
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