Genetic alterations in the RAS/RAF/mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma

BACKGROUND: The follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common histotype among papillary thyroid cancers (PTCs). Although the prognosis of FVPTC is similar to the conventional phenotype, differential diagnostic difficulties may not be uncommon with other follicul...

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Veröffentlicht in:	Cancer 2010-06, Vol.116 (12), p.2974-2983
Hauptverfasser:	Santarpia, Libero, Myers, Jeffrey N., Sherman, Steven I., Trimarchi, Francesco, Clayman, Gary L., El‐Naggar, Adel K.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Biological and medical sciences Carcinoma, Papillary, Follicular - genetics Codons Endocrinopathies follicular variant papillary thyroid cancer Fusion protein genetic alterations Glutamic acid Humans Malignant tumors MAP kinase MAP Kinase Signaling System - genetics Medical sciences mitogen‐activated protein kinase pathway Mutation Neuroblastoma Oncogenes papillary thyroid cancer papillary thyroid carcinoma Pax8 protein PAX8‐PPARγ translocations Peroxisome proliferator-activated receptors Phosphatidylinositol 3-Kinases - genetics phosphatidylinositol 3‐kinase pathway phosphorylation activation Polymerase chain reaction Prognosis Protein kinase Proto-Oncogene Proteins c-akt - genetics Proto-oncogenes PTEN protein raf Kinases - genetics Raf protein Ras protein ras Proteins - genetics Ret protein RET‐PTC rearrangements Sarcoma Signal transduction Signal Transduction - genetics thymoma Thyroid Neoplasms - genetics Thyroid. Thyroid axis (diseases) Transfection Translocation, Genetic Tumors valine Western blotting
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