Molecular studies on Abeta(42) induced genomic instability in aged rabbit brain

DNA stability and conformation are important in the life cycle of an organism. The DNA instability is postulated to be one of the risk factors for neuronal death in neurodegenerative disorders. Among all other risk factors, amyloid is one of the most important risk factor for neurodegeneration. Abet...

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Veröffentlicht in:	Neurochemistry international 2010-04, Vol.56 (5), p.655-662
Hauptverfasser:	Narasingappa, Ramesh B, Prahalad, Raichurkar K, Mannar, Shama Sundar N, Sathyanarayana, Rao T S, Hanumanthappa, Basavaraj K, Jagannatha, Rao Kosagisharaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Amyloid beta-Peptides - toxicity Animals Brain Chemistry - drug effects Brain Chemistry - genetics Circular Dichroism Deoxyribonuclease I - metabolism DNA - biosynthesis DNA - genetics DNA - isolation & purification DNA Damage - drug effects Electrophoresis, Agar Gel Ethidium - metabolism Hippocampus - pathology Magnetic Resonance Imaging Mesencephalon - pathology Nerve Degeneration - genetics Nerve Degeneration - pathology Nucleic Acid Conformation - drug effects Peptide Fragments - toxicity Prefrontal Cortex - pathology Rabbits Temperature
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