A Novel Chemokine-Receptor-5 (CCR5) Blocker, SCH532706, Has Differential Effects on CCR5+CD4+ and CCR5+CD8+ T Cell Numbers in Chronic HIV Infection

HIV treatment with CCR5 receptor blockers may impact CCR5(+) cell distribution. T cell subsets, plasmacytoid dendritic cells (PDC), and antigen-specific [Mycobacteria tuberculosis/avium (M.TB/MAI), cytomegalovirus (CMV), Herpes simplex (HSV), HIV-Gag] CD4(+) T cells were measured in untreated R5-tro...

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Veröffentlicht in:	AIDS research and human retroviruses 2010-06, Vol.26 (6), p.653-661
Hauptverfasser:	PETT, Sarah L, ZAUNDERS, John, BAILEY, Michelle, MURRAY, John, MACRAE, Karen, EMERY, Sean, COOPER, David A, KELLEHER, Anthony D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Biological and medical sciences CCR5 Receptor Antagonists CD4-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - drug effects Cytomegalovirus - immunology Dendritic Cells - drug effects Fundamental and applied biological sciences. Psychology Herpesvirus 1, Human - immunology HIV Infections - drug therapy Human viral diseases Humans Infectious diseases Leukocyte Count Male Medical sciences Microbiology Middle Aged Miscellaneous Mycobacterium tuberculosis - immunology T-Lymphocyte Subsets - drug effects Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology
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