Blocking angiotensin II Type 1 receptor triggers apoptotic cell death in human pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy with an annual mortality rate close to its annual incidence. We recently demonstrated that angiotensin II (AngII) type 1 receptor (AT1R) might be involved in PDA angiogenesis. This study evaluated the antiproliferative and proapoptot...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pancreas 2010-07, Vol.39 (5), p.581-594
Hauptverfasser:	Gong, Qiaoke, Davis, Molly, Chipitsyna, Galina, Yeo, Charles J, Arafat, Hwyda A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - pharmacology Apoptosis bcl-2-Associated X Protein - metabolism Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Caspase 3 - metabolism Cell Line, Tumor Humans Losartan - pharmacology Mutation Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Receptor, Angiotensin, Type 1 - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!