Short and Straightforward Synthesis of (−)-1-Deoxygalactonojirimycin

The mildness and low basicity of vinylzinc species functioning as a nucleophile in addition to α-chiral aldehydes is characterized by lack of epimerization of the vulnerable stereogenic center. This is demonstrated by a highly diastereoselective synthesis of 1-deoxygalactonojirimycin in eight steps...

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Veröffentlicht in:	Organic letters 2010-03, Vol.12 (6), p.1145-1147
Hauptverfasser:	Karjalainen, Oskari K, Passiniemi, Mikko, Koskinen, Ari M. P
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Deoxynojirimycin - analogs & derivatives 1-Deoxynojirimycin - chemical synthesis 1-Deoxynojirimycin - chemistry Glycoside Hydrolases - antagonists & inhibitors Molecular Structure Stereoisomerism
Online-Zugang:	Volltext
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