The nucleolus: a site of ribonucleoprotein maturation
The nucleolus is the site of ribosomal RNA synthesis, processing and ribosome maturation. Various small ribonucleoproteins also undergo maturation in the nucleolus, involving RNA modification and RNA–protein assembly. Such steps and other activities of small ribonucleoproteins also take place in Caj...
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| Veröffentlicht in: | Current opinion in cell biology 2003-06, Vol.15 (3), p.318-325 |
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| creator | Gerbi, Susan A Borovjagin, Anton V Lange, Thilo Sascha |
| description | The nucleolus is the site of ribosomal RNA synthesis, processing and ribosome maturation. Various small ribonucleoproteins also undergo maturation in the nucleolus, involving RNA modification and RNA–protein assembly. Such steps and other activities of small ribonucleoproteins also take place in Cajal (coiled) bodies. Events of ribosome biogenesis are found solely in the nucleolus, which is the final destination of small nucleolar RNAs after their traffic through Cajal bodies. However, nucleoli are just a stopping point in the intricate cellular traffic for small nuclear RNAs and other ribonucleoproteins. |
| doi_str_mv | 10.1016/S0955-0674(03)00049-8 |
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| ispartof | Current opinion in cell biology, 2003-06, Vol.15 (3), p.318-325 |
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| subjects | Animals Cell Nucleolus - physiology Humans Ribonucleoproteins - physiology Ribosomes - physiology |
| title | The nucleolus: a site of ribonucleoprotein maturation |
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