Fasciola hepatica: Histological changes in the reproductive structures of triclabendazole (TCBZ)-sensitive and TCBZ-resistant flukes after treatment in vivo with TCBZ and the related benzimidazole derivative, Compound Alpha

Twenty-four shed-reared lambs were each infected orally with 250 metacercariae of Fasciola hepatica, using either the triclabendazole (TCBZ)-sensitive Cullompton isolate or the TCBZ-resistant Sligo isolate. Twelve weeks after infection the lambs were treated with TCBZ (10 mg/kg) or with the experime...

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Veröffentlicht in:	Veterinary parasitology 2010-03, Vol.168 (3), p.240-254
Hauptverfasser:	Hanna, R.E.B., Edgar, H.W.J., McConnell, S., Toner, E., McConville, M., Brennan, G.P., Devine, C., Flanagan, A., Halferty, L., Meaney, M., Shaw, L., Moffett, D., McCoy, M., Fairweather, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - pharmacology Anthelmintics - therapeutic use Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Compound Alpha Drug Resistance - physiology Fasciola hepatica Fasciola hepatica - drug effects Fascioliasis - drug therapy Fascioliasis - parasitology Fascioliasis - veterinary Genitalia - drug effects Imidazoles - pharmacology Imidazoles - therapeutic use In vivo histology Naphthalenes - pharmacology Naphthalenes - therapeutic use Reproductive structures Sheep Sheep Diseases - drug therapy Sheep Diseases - parasitology TCBZ resistance Time Factors Triclabendazole
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