Continuous dopaminergic stimulation by pramipexole is effective to treat early morning akinesia in animal models of Parkinson's disease: A pharmacokinetic-pharmacodynamic study using in vivo microdialysis in rats

Short‐acting dopamine (DA) agonists are usually administered several times a day resulting in fluctuating plasma and brain levels. DA agonists providing continuous dopaminergic stimulation may achieve higher therapeutic benefit for example by alleviating nocturnal disturbances as well as early morni...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2010-07, Vol.64 (7), p.533-541
Hauptverfasser:	Ferger, Boris, Buck, Kerstin, Shimasaki, Makoto, Koros, Eliza, Voehringer, Patrizia, Buerger, Erich
Format:	Artikel
Sprache:	eng
Schlagworte:	Akinesia Animal models Animals Benzothiazoles - administration & dosage Benzothiazoles - pharmacokinetics Benzothiazoles - pharmacology Brain Catalepsy Catalepsy - chemically induced Catalepsy - drug therapy Catalepsy - metabolism Delayed-Action Preparations - metabolism Disease Models, Animal Dopamine Dopamine - metabolism Dopamine Agonists - administration & dosage Dopamine Agonists - pharmacokinetics Dopamine Agonists - pharmacology Dyskinesia, Drug-Induced - drug therapy Dyskinesia, Drug-Induced - metabolism Extracellular Space - drug effects Extracellular Space - metabolism Haloperidol in vivo microdialysis Infusion Pumps, Implantable Injections, Subcutaneous Male Microdialysis Motor activity Movement disorders Neurodegenerative diseases Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Parkinsonian Disorders - drug therapy Parkinsonian Disorders - metabolism Photoperiod pramipexole Rats Rats, Wistar Reserpine striatum Synapses Time Factors
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