Expression of the NR2B-NMDA receptor subunit and its Tbr-1/CINAP regulatory proteins in postmortem brain suggest altered receptor processing in schizophrenia

Several lines of evidence implicate aberrant glutamate neurotransmission in the pathophysiology of schizophrenia. In particular, compromised signaling through the N‐methyl‐D‐aspartate (NMDA) receptor has been linked to positive, negative, and cognitive symptoms of this illness. Studies in postmortem...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2010-07, Vol.64 (7), p.495-502
Hauptverfasser:	Kristiansen, Lars V., Patel, Sagar A., Haroutunian, Vahram, Meador-Woodruff, James H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Blotting, Western Brain Case-Control Studies Cognitive ability Cortex (prefrontal) Disks Large Homolog 4 Protein DNA-Binding Proteins Endoplasmic reticulum Endoplasmic Reticulum - metabolism Female glutamate Glutamic acid Glutamic acid receptors Glutamic acid receptors (ionotropic) Gyrus Cinguli - metabolism Humans Intracellular Signaling Peptides and Proteins - metabolism Male Membrane Proteins - metabolism membrane trafficking Mental disorders Middle Aged N-Methyl-D-aspartic acid receptors Neurotransmission Nuclear Proteins - metabolism postmortem postsynaptic density Postsynaptic density proteins Prefrontal Cortex - metabolism protein expression Receptors, N-Methyl-D-Aspartate - metabolism regulatory proteins Schizophrenia Schizophrenia - metabolism Synapses synthesis T-Box Domain Proteins - metabolism trafficking Transcription
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!