Solid state evaluation of some thalidomide raw materials

Thalidomide presents polymorphism and is a problematic drug due to its poor solubility and difficult tablet processability, which is the dosage form available in Brazil. In most cases, the pharmacopoeias specify do not address solid state characterization of drugs precisely. In this work, different...

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Veröffentlicht in:	International journal of pharmaceutics 2009-05, Vol.372 (1), p.17-23
Hauptverfasser:	Carini, J.P., Pavei, C., Silva, A.P.C., Machado, G., Mexias, A.S., Pereira, V.P., Fialho, S.L., Mayorga, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug Evaluation, Preclinical - methods General pharmacology Intrinsic dissolution Medical sciences Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymorphism Rietveld method Solid state characterization Solubility Thalidomide Thalidomide - analysis Thalidomide - chemistry X-ray diffraction X-Ray Diffraction - methods
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