Sipaucins A–C, sesquiterpenoids from Siparuna pauciflora
The phytochemical investigation of the leaves of Siparuna pauciflora yielded three novel sesquiterpenoids: the germacrane sipaucin A, the elemane sipaucin B and sipaucin C, comprising a new type of carbon skeleton. In addition, four known aporphine alkaloids— nor-boldine, boldine, laurotetanine, and...
Gespeichert in:
| Veröffentlicht in: | Phytochemistry (Oxford) 2003-06, Vol.63 (4), p.377-381 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 381 |
|---|---|
| container_issue | 4 |
| container_start_page | 377 |
| container_title | Phytochemistry (Oxford) |
| container_volume | 63 |
| creator | Jenett-Siems, Kristina Kraft, Carola Siems, Karsten Jakupovic, Jasmin Solis, Pablo N. Gupta, Mahabir P. Bienzle, Ulrich |
| description | The phytochemical investigation of the leaves of
Siparuna pauciflora yielded three novel sesquiterpenoids: the germacrane sipaucin A, the elemane sipaucin B and sipaucin C, comprising a new type of carbon skeleton. In addition, four known aporphine alkaloids—
nor-boldine, boldine, laurotetanine, and
N-methyl-laurotetanine—were obtained. The evaluation of the antiplasmodial activity of the isolated compounds against two strains of
Plasmodium falciparum (PoW, Dd2) showed a moderate activity of
nor-boldine.
From the leaves of
Siparuna pauciflora (Monimiaceae) three sesquiterpenoids—sipaucins A–C—were isolated together with four known aporphine alkaloids. |
| doi_str_mv | 10.1016/S0031-9422(03)00098-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_73332615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0031942203000980</els_id><sourcerecordid>73332615</sourcerecordid><originalsourceid>FETCH-LOGICAL-e209t-81ab424b9f51ec67ac26aec3c9b3832e64b7e492fb60e11e9674475ecab13f983</originalsourceid><addsrcrecordid>eNqF0ctKxDAUBuAgijOOPoLSlShYPUnapHEjw-ANBlyMrkOankKkN5Op4M538A19EjsX3bo6Z_Fx4Pw_IccULilQcbUA4DRWCWNnwM8BQGUx7JAxzSSPuQTYJeM_MiIHIbwOKE2F2CcjyqSENONjcr1wnemta0I0_f78ml1EAcNb75boO2xaV4So9G0drZjvGxOtdVm13hySvdJUAY-2c0Je7m6fZw_x_On-cTadx8hALeOMmjxhSa7KlKIV0lgmDFpuVc4zzlAkucREsTIXgJSiEjJJZIrW5JSXKuMTcrq52_n2rcew1LULFqvKNNj2QUvOORM0_RdSxTIpFAzwZAv7vMZCd97Vxn_o31gGcLMBOPz17tDrYB02Fgvn0S510TpNQa-K0Osi9CplDVyvixiWH2hbeXc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19287690</pqid></control><display><type>article</type><title>Sipaucins A–C, sesquiterpenoids from Siparuna pauciflora</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Jenett-Siems, Kristina ; Kraft, Carola ; Siems, Karsten ; Jakupovic, Jasmin ; Solis, Pablo N. ; Gupta, Mahabir P. ; Bienzle, Ulrich</creator><creatorcontrib>Jenett-Siems, Kristina ; Kraft, Carola ; Siems, Karsten ; Jakupovic, Jasmin ; Solis, Pablo N. ; Gupta, Mahabir P. ; Bienzle, Ulrich</creatorcontrib><description>The phytochemical investigation of the leaves of
Siparuna pauciflora yielded three novel sesquiterpenoids: the germacrane sipaucin A, the elemane sipaucin B and sipaucin C, comprising a new type of carbon skeleton. In addition, four known aporphine alkaloids—
nor-boldine, boldine, laurotetanine, and
N-methyl-laurotetanine—were obtained. The evaluation of the antiplasmodial activity of the isolated compounds against two strains of
Plasmodium falciparum (PoW, Dd2) showed a moderate activity of
nor-boldine.
From the leaves of
Siparuna pauciflora (Monimiaceae) three sesquiterpenoids—sipaucins A–C—were isolated together with four known aporphine alkaloids.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/S0031-9422(03)00098-0</identifier><identifier>PMID: 12770583</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antiprotozoal Agents - chemistry ; Antiprotozoal Agents - isolation & purification ; Antiprotozoal Agents - pharmacology ; Aporphine alkaloids ; Magnetic Resonance Spectroscopy ; Monimiaceae ; Monimiaceae - chemistry ; Plant Leaves - chemistry ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Sesquiterpenes - chemistry ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology ; Sesquiterpenoids ; Siparuna pauciflora</subject><ispartof>Phytochemistry (Oxford), 2003-06, Vol.63 (4), p.377-381</ispartof><rights>2003 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0031-9422(03)00098-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12770583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jenett-Siems, Kristina</creatorcontrib><creatorcontrib>Kraft, Carola</creatorcontrib><creatorcontrib>Siems, Karsten</creatorcontrib><creatorcontrib>Jakupovic, Jasmin</creatorcontrib><creatorcontrib>Solis, Pablo N.</creatorcontrib><creatorcontrib>Gupta, Mahabir P.</creatorcontrib><creatorcontrib>Bienzle, Ulrich</creatorcontrib><title>Sipaucins A–C, sesquiterpenoids from Siparuna pauciflora</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>The phytochemical investigation of the leaves of
Siparuna pauciflora yielded three novel sesquiterpenoids: the germacrane sipaucin A, the elemane sipaucin B and sipaucin C, comprising a new type of carbon skeleton. In addition, four known aporphine alkaloids—
nor-boldine, boldine, laurotetanine, and
N-methyl-laurotetanine—were obtained. The evaluation of the antiplasmodial activity of the isolated compounds against two strains of
Plasmodium falciparum (PoW, Dd2) showed a moderate activity of
nor-boldine.
From the leaves of
Siparuna pauciflora (Monimiaceae) three sesquiterpenoids—sipaucins A–C—were isolated together with four known aporphine alkaloids.</description><subject>Animals</subject><subject>Antiprotozoal Agents - chemistry</subject><subject>Antiprotozoal Agents - isolation & purification</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Aporphine alkaloids</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Monimiaceae</subject><subject>Monimiaceae - chemistry</subject><subject>Plant Leaves - chemistry</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Sesquiterpenes - chemistry</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Sesquiterpenoids</subject><subject>Siparuna pauciflora</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctKxDAUBuAgijOOPoLSlShYPUnapHEjw-ANBlyMrkOankKkN5Op4M538A19EjsX3bo6Z_Fx4Pw_IccULilQcbUA4DRWCWNnwM8BQGUx7JAxzSSPuQTYJeM_MiIHIbwOKE2F2CcjyqSENONjcr1wnemta0I0_f78ml1EAcNb75boO2xaV4So9G0drZjvGxOtdVm13hySvdJUAY-2c0Je7m6fZw_x_On-cTadx8hALeOMmjxhSa7KlKIV0lgmDFpuVc4zzlAkucREsTIXgJSiEjJJZIrW5JSXKuMTcrq52_n2rcew1LULFqvKNNj2QUvOORM0_RdSxTIpFAzwZAv7vMZCd97Vxn_o31gGcLMBOPz17tDrYB02Fgvn0S510TpNQa-K0Osi9CplDVyvixiWH2hbeXc</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Jenett-Siems, Kristina</creator><creator>Kraft, Carola</creator><creator>Siems, Karsten</creator><creator>Jakupovic, Jasmin</creator><creator>Solis, Pablo N.</creator><creator>Gupta, Mahabir P.</creator><creator>Bienzle, Ulrich</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Sipaucins A–C, sesquiterpenoids from Siparuna pauciflora</title><author>Jenett-Siems, Kristina ; Kraft, Carola ; Siems, Karsten ; Jakupovic, Jasmin ; Solis, Pablo N. ; Gupta, Mahabir P. ; Bienzle, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e209t-81ab424b9f51ec67ac26aec3c9b3832e64b7e492fb60e11e9674475ecab13f983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antiprotozoal Agents - chemistry</topic><topic>Antiprotozoal Agents - isolation & purification</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Aporphine alkaloids</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Monimiaceae</topic><topic>Monimiaceae - chemistry</topic><topic>Plant Leaves - chemistry</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Sesquiterpenoids</topic><topic>Siparuna pauciflora</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jenett-Siems, Kristina</creatorcontrib><creatorcontrib>Kraft, Carola</creatorcontrib><creatorcontrib>Siems, Karsten</creatorcontrib><creatorcontrib>Jakupovic, Jasmin</creatorcontrib><creatorcontrib>Solis, Pablo N.</creatorcontrib><creatorcontrib>Gupta, Mahabir P.</creatorcontrib><creatorcontrib>Bienzle, Ulrich</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jenett-Siems, Kristina</au><au>Kraft, Carola</au><au>Siems, Karsten</au><au>Jakupovic, Jasmin</au><au>Solis, Pablo N.</au><au>Gupta, Mahabir P.</au><au>Bienzle, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sipaucins A–C, sesquiterpenoids from Siparuna pauciflora</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2003-06</date><risdate>2003</risdate><volume>63</volume><issue>4</issue><spage>377</spage><epage>381</epage><pages>377-381</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>The phytochemical investigation of the leaves of
Siparuna pauciflora yielded three novel sesquiterpenoids: the germacrane sipaucin A, the elemane sipaucin B and sipaucin C, comprising a new type of carbon skeleton. In addition, four known aporphine alkaloids—
nor-boldine, boldine, laurotetanine, and
N-methyl-laurotetanine—were obtained. The evaluation of the antiplasmodial activity of the isolated compounds against two strains of
Plasmodium falciparum (PoW, Dd2) showed a moderate activity of
nor-boldine.
From the leaves of
Siparuna pauciflora (Monimiaceae) three sesquiterpenoids—sipaucins A–C—were isolated together with four known aporphine alkaloids.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12770583</pmid><doi>10.1016/S0031-9422(03)00098-0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9422 |
| ispartof | Phytochemistry (Oxford), 2003-06, Vol.63 (4), p.377-381 |
| issn | 0031-9422 1873-3700 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73332615 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antiprotozoal Agents - chemistry Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Aporphine alkaloids Magnetic Resonance Spectroscopy Monimiaceae Monimiaceae - chemistry Plant Leaves - chemistry Plasmodium falciparum Plasmodium falciparum - drug effects Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Sesquiterpenoids Siparuna pauciflora |
| title | Sipaucins A–C, sesquiterpenoids from Siparuna pauciflora |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T12%3A53%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sipaucins%20A%E2%80%93C,%20sesquiterpenoids%20from%20Siparuna%20pauciflora&rft.jtitle=Phytochemistry%20(Oxford)&rft.au=Jenett-Siems,%20Kristina&rft.date=2003-06&rft.volume=63&rft.issue=4&rft.spage=377&rft.epage=381&rft.pages=377-381&rft.issn=0031-9422&rft.eissn=1873-3700&rft_id=info:doi/10.1016/S0031-9422(03)00098-0&rft_dat=%3Cproquest_pubme%3E73332615%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19287690&rft_id=info:pmid/12770583&rft_els_id=S0031942203000980&rfr_iscdi=true |