Retinal nerve fiber layer thickness in patients with retinitis pigmentosa
Purpose To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP). Design Cross-sectional observational study. Methods One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equ...
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| Veröffentlicht in: | Eye (London) 2009-03, Vol.23 (3), p.561-566 |
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| creator | Oishi, A Otani, A Sasahara, M Kurimoto, M Nakamura, H Kojima, H Yoshimura, N |
| description | Purpose
To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP).
Design
Cross-sectional observational study.
Methods
One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equivalent refractive error, visual acuity, and the extent of visual field defect on RNFL thickness measured with optical coherence tomography were analyzed by a multiple linear regression model.
Results
The average RNFL thickness was 104.1±21.7
μ
m. The multiple
R
2
for the model was 0.349. Among the variables studied, ageing and being male were significant risk factors for thinner RNFL thickness. RNFL thickness was not correlated with inheritance trait, laterality, refractive error, visual acuity, or the extent of visual field defect.
Conclusion
RNFL thickness in RP patients was not correlated with visual function but ageing as in the normal subjects. Currently proposed therapies, including photoreceptor rescue/transplantation and visual prosthesis, are based on the premise that the inner retinal structures are relatively retained despite the profound loss of photoreceptors. The present result supports this notion. |
| doi_str_mv | 10.1038/eye.2008.63 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733321170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1661504301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-d1d43b874d31ee72f2fb432ad725f292822804bd226fcf9ee1aa4a0731326303</originalsourceid><addsrcrecordid>eNp90UtLxDAQAOAgiq6Pk3ctgnrQrskkbbpHEV8gCOLBW0nbiUa76Zqkyv57U3ZREPGSQObLZDJDyC6jY0Z5cYZzHAOlxTjnK2TEhMzTTGRilYzoJKMpADxtkE3vXymNQUnXyQYruBCTjI3I7QMGY1WbWHQfmGhToUtaNY9reDH1m0XvE2OTmQoGbfDJpwkviRsumWB8MjPP03jeebVN1rRqPe4s9y3yeHX5eHGT3t1f316c36W1kCKkDWsErwopGs4QJWjQleCgGgmZhgkUAAUVVQOQ61pPEJlSQlHJGYecU75FjhdpZ65779GHcmp8jW2rLHa9LyXnHBiTgzz6VwLNCp6LAR78gq9d72JToomdynisJaKTBapd571DXc6cmSo3LxkthzmUcQ7lMIcy51HvLVP21RSbH7tsfASHS6B8rVrtlK2N_3YQfysEk9GdLpyPIfuM7qe2v9_dX3CrQu_wO180A4niCw_NqJk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218353226</pqid></control><display><type>article</type><title>Retinal nerve fiber layer thickness in patients with retinitis pigmentosa</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Oishi, A ; Otani, A ; Sasahara, M ; Kurimoto, M ; Nakamura, H ; Kojima, H ; Yoshimura, N</creator><creatorcontrib>Oishi, A ; Otani, A ; Sasahara, M ; Kurimoto, M ; Nakamura, H ; Kojima, H ; Yoshimura, N</creatorcontrib><description>Purpose
To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP).
Design
Cross-sectional observational study.
Methods
One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equivalent refractive error, visual acuity, and the extent of visual field defect on RNFL thickness measured with optical coherence tomography were analyzed by a multiple linear regression model.
Results
The average RNFL thickness was 104.1±21.7
μ
m. The multiple
R
2
for the model was 0.349. Among the variables studied, ageing and being male were significant risk factors for thinner RNFL thickness. RNFL thickness was not correlated with inheritance trait, laterality, refractive error, visual acuity, or the extent of visual field defect.
Conclusion
RNFL thickness in RP patients was not correlated with visual function but ageing as in the normal subjects. Currently proposed therapies, including photoreceptor rescue/transplantation and visual prosthesis, are based on the premise that the inner retinal structures are relatively retained despite the profound loss of photoreceptors. The present result supports this notion.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2008.63</identifier><identifier>PMID: 18344951</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aged ; Aging - pathology ; Biological and medical sciences ; clinical-study ; Epidemiologic Methods ; Female ; Humans ; Laboratory Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscellaneous ; Nerve Fibers - pathology ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Retinal Neurons - pathology ; Retinitis Pigmentosa - pathology ; Retinitis Pigmentosa - physiopathology ; Retinopathies ; Sex Factors ; Surgery ; Surgical Oncology ; Tomography, Optical Coherence ; Visual Acuity ; Visual Fields</subject><ispartof>Eye (London), 2009-03, Vol.23 (3), p.561-566</ispartof><rights>Royal College of Ophthalmologists 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-d1d43b874d31ee72f2fb432ad725f292822804bd226fcf9ee1aa4a0731326303</citedby><cites>FETCH-LOGICAL-c474t-d1d43b874d31ee72f2fb432ad725f292822804bd226fcf9ee1aa4a0731326303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/eye.2008.63$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/eye.2008.63$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21324417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18344951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oishi, A</creatorcontrib><creatorcontrib>Otani, A</creatorcontrib><creatorcontrib>Sasahara, M</creatorcontrib><creatorcontrib>Kurimoto, M</creatorcontrib><creatorcontrib>Nakamura, H</creatorcontrib><creatorcontrib>Kojima, H</creatorcontrib><creatorcontrib>Yoshimura, N</creatorcontrib><title>Retinal nerve fiber layer thickness in patients with retinitis pigmentosa</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP).
Design
Cross-sectional observational study.
Methods
One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equivalent refractive error, visual acuity, and the extent of visual field defect on RNFL thickness measured with optical coherence tomography were analyzed by a multiple linear regression model.
Results
The average RNFL thickness was 104.1±21.7
μ
m. The multiple
R
2
for the model was 0.349. Among the variables studied, ageing and being male were significant risk factors for thinner RNFL thickness. RNFL thickness was not correlated with inheritance trait, laterality, refractive error, visual acuity, or the extent of visual field defect.
Conclusion
RNFL thickness in RP patients was not correlated with visual function but ageing as in the normal subjects. Currently proposed therapies, including photoreceptor rescue/transplantation and visual prosthesis, are based on the premise that the inner retinal structures are relatively retained despite the profound loss of photoreceptors. The present result supports this notion.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging - pathology</subject><subject>Biological and medical sciences</subject><subject>clinical-study</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Retinal Neurons - pathology</subject><subject>Retinitis Pigmentosa - pathology</subject><subject>Retinitis Pigmentosa - physiopathology</subject><subject>Retinopathies</subject><subject>Sex Factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity</subject><subject>Visual Fields</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90UtLxDAQAOAgiq6Pk3ctgnrQrskkbbpHEV8gCOLBW0nbiUa76Zqkyv57U3ZREPGSQObLZDJDyC6jY0Z5cYZzHAOlxTjnK2TEhMzTTGRilYzoJKMpADxtkE3vXymNQUnXyQYruBCTjI3I7QMGY1WbWHQfmGhToUtaNY9reDH1m0XvE2OTmQoGbfDJpwkviRsumWB8MjPP03jeebVN1rRqPe4s9y3yeHX5eHGT3t1f316c36W1kCKkDWsErwopGs4QJWjQleCgGgmZhgkUAAUVVQOQ61pPEJlSQlHJGYecU75FjhdpZ65779GHcmp8jW2rLHa9LyXnHBiTgzz6VwLNCp6LAR78gq9d72JToomdynisJaKTBapd571DXc6cmSo3LxkthzmUcQ7lMIcy51HvLVP21RSbH7tsfASHS6B8rVrtlK2N_3YQfysEk9GdLpyPIfuM7qe2v9_dX3CrQu_wO180A4niCw_NqJk</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Oishi, A</creator><creator>Otani, A</creator><creator>Sasahara, M</creator><creator>Kurimoto, M</creator><creator>Nakamura, H</creator><creator>Kojima, H</creator><creator>Yoshimura, N</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Retinal nerve fiber layer thickness in patients with retinitis pigmentosa</title><author>Oishi, A ; Otani, A ; Sasahara, M ; Kurimoto, M ; Nakamura, H ; Kojima, H ; Yoshimura, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-d1d43b874d31ee72f2fb432ad725f292822804bd226fcf9ee1aa4a0731326303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging - pathology</topic><topic>Biological and medical sciences</topic><topic>clinical-study</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Retinal Neurons - pathology</topic><topic>Retinitis Pigmentosa - pathology</topic><topic>Retinitis Pigmentosa - physiopathology</topic><topic>Retinopathies</topic><topic>Sex Factors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oishi, A</creatorcontrib><creatorcontrib>Otani, A</creatorcontrib><creatorcontrib>Sasahara, M</creatorcontrib><creatorcontrib>Kurimoto, M</creatorcontrib><creatorcontrib>Nakamura, H</creatorcontrib><creatorcontrib>Kojima, H</creatorcontrib><creatorcontrib>Yoshimura, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oishi, A</au><au>Otani, A</au><au>Sasahara, M</au><au>Kurimoto, M</au><au>Nakamura, H</au><au>Kojima, H</au><au>Yoshimura, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal nerve fiber layer thickness in patients with retinitis pigmentosa</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>23</volume><issue>3</issue><spage>561</spage><epage>566</epage><pages>561-566</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>Purpose
To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP).
Design
Cross-sectional observational study.
Methods
One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equivalent refractive error, visual acuity, and the extent of visual field defect on RNFL thickness measured with optical coherence tomography were analyzed by a multiple linear regression model.
Results
The average RNFL thickness was 104.1±21.7
μ
m. The multiple
R
2
for the model was 0.349. Among the variables studied, ageing and being male were significant risk factors for thinner RNFL thickness. RNFL thickness was not correlated with inheritance trait, laterality, refractive error, visual acuity, or the extent of visual field defect.
Conclusion
RNFL thickness in RP patients was not correlated with visual function but ageing as in the normal subjects. Currently proposed therapies, including photoreceptor rescue/transplantation and visual prosthesis, are based on the premise that the inner retinal structures are relatively retained despite the profound loss of photoreceptors. The present result supports this notion.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18344951</pmid><doi>10.1038/eye.2008.63</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-222X |
| ispartof | Eye (London), 2009-03, Vol.23 (3), p.561-566 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733321170 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aging - pathology Biological and medical sciences clinical-study Epidemiologic Methods Female Humans Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous Nerve Fibers - pathology Ophthalmology Pharmaceutical Sciences/Technology Retinal Neurons - pathology Retinitis Pigmentosa - pathology Retinitis Pigmentosa - physiopathology Retinopathies Sex Factors Surgery Surgical Oncology Tomography, Optical Coherence Visual Acuity Visual Fields |
| title | Retinal nerve fiber layer thickness in patients with retinitis pigmentosa |
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