PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage

Summary Objective The effect of the prostaglandin E2 (PGE2) signal through prostaglandin E receptor 2 (EP2) receptors on the repair of injured articular cartilage was investigated using a selective agonist for EP2. Methods Chondral and osteochondral defects were prepared on the rabbit femoral concav...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Osteoarthritis and cartilage 2009-04, Vol.17 (4), p.529-538
Hauptverfasser:	Otsuka, S., M.D, Aoyama, T., M.D., Ph.D, Furu, M., M.D, Ito, K., M.D, Jin, Y., M.D, Nasu, A., M.D, Fukiage, K., M.D, Kohno, Y., M.D., Ph.D, Maruyama, T., Ph.D, Kanaji, T, Nishiura, A., Ph.D, Sugihara, H, Fujimura, S, Otsuka, T., M.D., Ph.D, Nakamura, T., M.D., Ph.D, Toguchida, J., M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Animals C-Reactive Protein - metabolism Cartilage Cartilage, Articular - drug effects Cartilage, Articular - injuries Cartilage, Articular - pathology Cartilage, Articular - physiology Cell Proliferation - drug effects Defect Dinoprostone - physiology Disease Models, Animal Drug Evaluation, Preclinical - methods EP2 Matrix Metalloproteinase 3 - metabolism Osteoarthritis PGE2 Rabbits Receptors, Prostaglandin E - agonists Receptors, Prostaglandin E - physiology Receptors, Prostaglandin E, EP2 Subtype Regeneration - drug effects Regeneration - physiology Repair Reverse Transcriptase Polymerase Chain Reaction - methods Rheumatology Synovial Fluid - metabolism Synovial Membrane - drug effects Synovial Membrane - pathology Therapeutic drug Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!