Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors

The efficacy of current anti-cancer gene therapies is limited by the inability of gene vectors to penetrate the poorly vascularized, hypoxic regions of tumors, leaving these sites untreated. We describe a new approach for targeting gene therapy to these sites, which employs an attenuated strain of t...

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Veröffentlicht in:	Gene therapy 2009-03, Vol.16 (3), p.329-339
Hauptverfasser:	Ryan, R M, Green, J, Williams, P J, Tazzyman, S, Hunt, S, Harmey, J H, Kehoe, S C, Lewis, C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Bacteria Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Breast cancer Cancer Care and treatment Cell Biology Cell Death Cell Hypoxia - physiology Coculture Techniques Cytotoxicity Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Expression vectors Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Targeting Gene Therapy Genes, Reporter Genetic aspects Genetic Therapy - methods Genetic vectors Genetic Vectors - pharmacokinetics Health aspects Health. Pharmaceutical industry Hemolysin Proteins - genetics Hemolysin Proteins - metabolism Human Genetics Hypoxia Industrial applications and implications. Economical aspects Mammary gland Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - therapy Medical sciences Methods Mice Mice, Inbred BALB C Mutagenesis, Site-Directed Nanotechnology Necrosis Oncology original-article Reporter gene Salmonella typhimurium Salmonella typhimurium - genetics Solid tumors Spheroids Spheroids, Cellular Tissue Distribution Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor Cells, Cultured Tumors β-Galactosidase
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