Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2

The proto-oncogene c-myb is overexpressed in human colon cancer cells. c-myb is known to be affected by estrogen in some breast cancers and leukemias. However, the mechanism of c-myb regulation via estrogen in colon cancer requires further investigation. Human COLO-205 colon cancer cells were cultur...

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Veröffentlicht in:	Tumor biology 2010, Vol.31 (1), p.16-22
Hauptverfasser:	Wilkins, Heather R., Doucet, Kristin, Duke, Victoria, Morra, Amber, Johnson, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Cellular biology Colonic Neoplasms - chemistry Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Colorectal cancer Estradiol - pharmacology Estrogens Genes Humans Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-myb - analysis Receptors, Estrogen - analysis Research Article RNA, Small Interfering - genetics Transcription, Genetic - drug effects
Online-Zugang:	Volltext
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