Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement
Introduction Plain radiography, bone scintigraphy, digital subtraction arthrography and various other techniques can be used to evaluate loosening of hip replacements. These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the re...
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| Veröffentlicht in: | Archives of orthopaedic and trauma surgery 2010-04, Vol.130 (4), p.441-445 |
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| creator | Landgraeber, Stefan Löer, Franz Heep, Hansjörg Classen, Tim Grabellus, Florian Totsch, Martin von Knoch, Marius |
| description | Introduction
Plain radiography, bone scintigraphy, digital subtraction arthrography and various other techniques can be used to evaluate loosening of hip replacements. These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the results are not conclusive.
Method
The osteoclast biomarkers tartrate-resistant acid phosphatase 5b (TRAP 5b) and C-terminal telopeptides of type I collagen (CTX) in serum taken from 12 patients with aseptic loosening were measured. Serum samples from 24 other patients, 12 with an intact arthroplasty and 12 without any kind of joint replacement, served as control groups.
Results
The serum level of CTX was increased in comparison to the control groups, but the differences were not significant. In contrast, the increase in TRAP 5b in patients with aseptic loosening was highly significant (
P
|
| doi_str_mv | 10.1007/s00402-009-0905-x |
| format | Article |
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Plain radiography, bone scintigraphy, digital subtraction arthrography and various other techniques can be used to evaluate loosening of hip replacements. These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the results are not conclusive.
Method
The osteoclast biomarkers tartrate-resistant acid phosphatase 5b (TRAP 5b) and C-terminal telopeptides of type I collagen (CTX) in serum taken from 12 patients with aseptic loosening were measured. Serum samples from 24 other patients, 12 with an intact arthroplasty and 12 without any kind of joint replacement, served as control groups.
Results
The serum level of CTX was increased in comparison to the control groups, but the differences were not significant. In contrast, the increase in TRAP 5b in patients with aseptic loosening was highly significant (
P
< 0.001). A TRAP 5b value of 3.365 U/L was determined as a cut-off value, giving a sensitivity of 83.3% and specificity of 91.7% to differentiate the patients with aseptic loosening from those with an intact arthroplasty. Measurement of serum TRAP 5b may be a clinically relevant assay for monitoring patients after arthroplasty.</description><identifier>ISSN: 0936-8051</identifier><identifier>EISSN: 1434-3916</identifier><identifier>DOI: 10.1007/s00402-009-0905-x</identifier><identifier>PMID: 19513735</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acid Phosphatase - blood ; Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip - adverse effects ; Biomarkers - blood ; Collagen Type I ; Female ; Hip Prosthesis - adverse effects ; Humans ; Isoenzymes - blood ; Joint surgery ; Male ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Orthopaedic Surgery ; Orthopedics ; Peptide Fragments - blood ; Peptides ; Phosphatase ; Procollagen - blood ; Prosthesis Failure ; Tartrate-Resistant Acid Phosphatase</subject><ispartof>Archives of orthopaedic and trauma surgery, 2010-04, Vol.130 (4), p.441-445</ispartof><rights>Springer-Verlag 2009</rights><rights>Archives of Orthopaedic and Trauma Surgery is a copyright of Springer, (2009). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-2c2f57f3fad3d375befa82df1b11de54c569536c15044e1aa4ba7dbc9337a983</citedby><cites>FETCH-LOGICAL-c371t-2c2f57f3fad3d375befa82df1b11de54c569536c15044e1aa4ba7dbc9337a983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00402-009-0905-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00402-009-0905-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19513735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Landgraeber, Stefan</creatorcontrib><creatorcontrib>Löer, Franz</creatorcontrib><creatorcontrib>Heep, Hansjörg</creatorcontrib><creatorcontrib>Classen, Tim</creatorcontrib><creatorcontrib>Grabellus, Florian</creatorcontrib><creatorcontrib>Totsch, Martin</creatorcontrib><creatorcontrib>von Knoch, Marius</creatorcontrib><title>Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement</title><title>Archives of orthopaedic and trauma surgery</title><addtitle>Arch Orthop Trauma Surg</addtitle><addtitle>Arch Orthop Trauma Surg</addtitle><description>Introduction
Plain radiography, bone scintigraphy, digital subtraction arthrography and various other techniques can be used to evaluate loosening of hip replacements. These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the results are not conclusive.
Method
The osteoclast biomarkers tartrate-resistant acid phosphatase 5b (TRAP 5b) and C-terminal telopeptides of type I collagen (CTX) in serum taken from 12 patients with aseptic loosening were measured. Serum samples from 24 other patients, 12 with an intact arthroplasty and 12 without any kind of joint replacement, served as control groups.
Results
The serum level of CTX was increased in comparison to the control groups, but the differences were not significant. In contrast, the increase in TRAP 5b in patients with aseptic loosening was highly significant (
P
< 0.001). A TRAP 5b value of 3.365 U/L was determined as a cut-off value, giving a sensitivity of 83.3% and specificity of 91.7% to differentiate the patients with aseptic loosening from those with an intact arthroplasty. Measurement of serum TRAP 5b may be a clinically relevant assay for monitoring patients after arthroplasty.</description><subject>Acid Phosphatase - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthroplasty, Replacement, Hip - adverse effects</subject><subject>Biomarkers - blood</subject><subject>Collagen Type I</subject><subject>Female</subject><subject>Hip Prosthesis - adverse effects</subject><subject>Humans</subject><subject>Isoenzymes - blood</subject><subject>Joint surgery</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Orthopaedic Surgery</subject><subject>Orthopedics</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Phosphatase</subject><subject>Procollagen - blood</subject><subject>Prosthesis Failure</subject><subject>Tartrate-Resistant Acid Phosphatase</subject><issn>0936-8051</issn><issn>1434-3916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kcFqGzEQhkVpaZy0D9BLEfTQk1rNauX1HotJm0CgF9_FrDSyN92VtpIMydP0VStjQ6DQkw7z_d-g-Rn7APILSNl9zVK2shFS9kL2UounV2wFrWqF6mH9mq1kr9ZiIzVcseucH6WEZtPLt-wKeg2qU3rF_uwwlYSFRKI85oKhcLSj48sh5uWABTNxPXAMjm9FoTSPASdeaIoLLWV0lHn0vDwvxO-5jdOEewocM58x_aKUuY-JuxH3IVb_ia3GGrR8ijFTGMOeo69iXmKp5sO48ETLhJZmCuUde-NxyvT-8t6w3ffb3fZOPPz8cb_99iCs6qCIxjZed155dMqpTg_kcdM4DwOAI91ave61WlvQsm0JENsBOzfYXqkO-426YZ_P2iXF30fKxcxjtlR_Eyges-mUUjWrT-Snf8jHeEz1Jtk0zRqqC1qoFJwpm2LOibxZ0lgv8mxAmlN35tydqd2ZU3fmqWY-XszHYSb3kriUVYHmDOQ6CntKL6v_b_0LG26n_A</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Landgraeber, Stefan</creator><creator>Löer, Franz</creator><creator>Heep, Hansjörg</creator><creator>Classen, Tim</creator><creator>Grabellus, Florian</creator><creator>Totsch, Martin</creator><creator>von Knoch, Marius</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement</title><author>Landgraeber, Stefan ; Löer, Franz ; Heep, Hansjörg ; Classen, Tim ; Grabellus, Florian ; Totsch, Martin ; von Knoch, Marius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-2c2f57f3fad3d375befa82df1b11de54c569536c15044e1aa4ba7dbc9337a983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acid Phosphatase - blood</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthroplasty, Replacement, Hip - adverse effects</topic><topic>Biomarkers - blood</topic><topic>Collagen Type I</topic><topic>Female</topic><topic>Hip Prosthesis - adverse effects</topic><topic>Humans</topic><topic>Isoenzymes - blood</topic><topic>Joint surgery</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Orthopaedic Surgery</topic><topic>Orthopedics</topic><topic>Peptide Fragments - blood</topic><topic>Peptides</topic><topic>Phosphatase</topic><topic>Procollagen - blood</topic><topic>Prosthesis Failure</topic><topic>Tartrate-Resistant Acid Phosphatase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landgraeber, Stefan</creatorcontrib><creatorcontrib>Löer, Franz</creatorcontrib><creatorcontrib>Heep, Hansjörg</creatorcontrib><creatorcontrib>Classen, Tim</creatorcontrib><creatorcontrib>Grabellus, Florian</creatorcontrib><creatorcontrib>Totsch, Martin</creatorcontrib><creatorcontrib>von Knoch, Marius</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of orthopaedic and trauma surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landgraeber, Stefan</au><au>Löer, Franz</au><au>Heep, Hansjörg</au><au>Classen, Tim</au><au>Grabellus, Florian</au><au>Totsch, Martin</au><au>von Knoch, Marius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement</atitle><jtitle>Archives of orthopaedic and trauma surgery</jtitle><stitle>Arch Orthop Trauma Surg</stitle><addtitle>Arch Orthop Trauma Surg</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>130</volume><issue>4</issue><spage>441</spage><epage>445</epage><pages>441-445</pages><issn>0936-8051</issn><eissn>1434-3916</eissn><abstract>Introduction
Plain radiography, bone scintigraphy, digital subtraction arthrography and various other techniques can be used to evaluate loosening of hip replacements. These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the results are not conclusive.
Method
The osteoclast biomarkers tartrate-resistant acid phosphatase 5b (TRAP 5b) and C-terminal telopeptides of type I collagen (CTX) in serum taken from 12 patients with aseptic loosening were measured. Serum samples from 24 other patients, 12 with an intact arthroplasty and 12 without any kind of joint replacement, served as control groups.
Results
The serum level of CTX was increased in comparison to the control groups, but the differences were not significant. In contrast, the increase in TRAP 5b in patients with aseptic loosening was highly significant (
P
< 0.001). A TRAP 5b value of 3.365 U/L was determined as a cut-off value, giving a sensitivity of 83.3% and specificity of 91.7% to differentiate the patients with aseptic loosening from those with an intact arthroplasty. Measurement of serum TRAP 5b may be a clinically relevant assay for monitoring patients after arthroplasty.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19513735</pmid><doi>10.1007/s00402-009-0905-x</doi><tpages>5</tpages></addata></record> |
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| subjects | Acid Phosphatase - blood Adult Aged Aged, 80 and over Arthroplasty, Replacement, Hip - adverse effects Biomarkers - blood Collagen Type I Female Hip Prosthesis - adverse effects Humans Isoenzymes - blood Joint surgery Male Medical diagnosis Medicine Medicine & Public Health Middle Aged Orthopaedic Surgery Orthopedics Peptide Fragments - blood Peptides Phosphatase Procollagen - blood Prosthesis Failure Tartrate-Resistant Acid Phosphatase |
| title | Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement |
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