Antibiotherapy and pathogenesis of uncomplicated UTI: difficult relationships

In a time when conventional antibiotics are becoming increasingly less effective for treatment of infections, the relationship between bacteria and antimicrobial resistance is becoming more and more complicated. This paper provides a current review of studies reported in the literature pertaining to...

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Veröffentlicht in:Journal of applied microbiology 2009-06, Vol.106 (6), p.1779-1791
Hauptverfasser: Moura, A, Nicolau, A, Hooton, T, Azeredo, J
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container_end_page 1791
container_issue 6
container_start_page 1779
container_title Journal of applied microbiology
container_volume 106
creator Moura, A
Nicolau, A
Hooton, T
Azeredo, J
description In a time when conventional antibiotics are becoming increasingly less effective for treatment of infections, the relationship between bacteria and antimicrobial resistance is becoming more and more complicated. This paper provides a current review of studies reported in the literature pertaining to the antibiotherapy of human urinary tract infections (UTI), in a way that helps the reader direct a bibliographic search and develop an integrated perspective of the subject. Highlights are given to (bio)pathogenesis of uncomplicated cystitis. Features associated with the antibiotherapy of UTI such as development of resistance are presented in the text systematically. This review discusses recent advances in the understanding of how the predominant uropathogen Escherichia coli interacts with its host and leads to infection; so one can understand some of the reasons behind antibiotherapy failures.
doi_str_mv 10.1111/j.1365-2672.2008.04115.x
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source MEDLINE; Wiley Journals; Oxford University Press Journals All Titles (1996-Current)
subjects Anti-Bacterial Agents - therapeutic use
antibiotherapy
Bacterial Infections - drug therapy
Biological and medical sciences
Drug Resistance, Bacterial
E. coli
Escherichia coli
Fundamental and applied biological sciences. Psychology
Humans
Microbiology
pathogenesis
resistance
Urinary Tract Infections - drug therapy
Urinary Tract Infections - microbiology
UTI
title Antibiotherapy and pathogenesis of uncomplicated UTI: difficult relationships
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