Downregulation of NF-kappaB signaling by mutant huntingtin proteins induces oxidative stress and cell death

Accumulation of abnormal proteins and endoplasmic reticulum stress accompany neurodegenerative diseases including Huntington's disease. We show that the expression of mutant huntingtin proteins with extended polyglutamine repeats differentially affected endoplasmic reticulum signaling cascades...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2010-06, Vol.67 (11), p.1929-1941
Hauptverfasser:	Reijonen, Sami, Kukkonen, Jyrki P, Hyrskyluoto, Alise, Kivinen, Jenny, Kairisalo, Minna, Takei, Nobuyuki, Lindholm, Dan, Korhonen, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Calcium Signaling Calcium-Binding Proteins - metabolism Calpain - metabolism Cell Death Cell Line DNA Primers - genetics Down-Regulation Humans Huntingtin Protein Mitochondrial Proteins - metabolism Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism NF-kappa B - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidative Stress PC12 Cells Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction Superoxide Dismutase - metabolism Thioredoxins - metabolism Transcription Factor RelA - metabolism
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