Comorbidities of Obsessive and Compulsive Symptoms in Huntingtonʼs Disease
Although current reports document a high rate of obsessive and compulsive symptoms (O/Cs) in Huntingtonʼs disease (HD), there have been no studies published that have made an attempt to identify comorbidities of O/Cs in HD. We examined O/Cs in 1642 individuals with a diagnosis of HD. Of those endors...
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| Veröffentlicht in: | The journal of nervous and mental disease 2010-05, Vol.198 (5), p.334-338 |
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| creator | Anderson, Karen E Gehl, Carissa R Marder, Karen S Beglinger, Leigh J Paulsen, Jane S |
| description | Although current reports document a high rate of obsessive and compulsive symptoms (O/Cs) in Huntingtonʼs disease (HD), there have been no studies published that have made an attempt to identify comorbidities of O/Cs in HD. We examined O/Cs in 1642 individuals with a diagnosis of HD. Of those endorsing significant O/Cs (27.2%), nearly one-quarter reported obtaining treatment for obsessive compulsive disorder. Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individuals with HD and O/Cs endorsed significantly higher psychiatric comorbidities of depression, suicidal ideation, aggression, delusions, and hallucinations. Participants with the most severe O/Cs and worse performance on the Stroop task, a measure of executive function. Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan. |
| doi_str_mv | 10.1097/NMD.0b013e3181da852a |
| format | Article |
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We examined O/Cs in 1642 individuals with a diagnosis of HD. Of those endorsing significant O/Cs (27.2%), nearly one-quarter reported obtaining treatment for obsessive compulsive disorder. Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individuals with HD and O/Cs endorsed significantly higher psychiatric comorbidities of depression, suicidal ideation, aggression, delusions, and hallucinations. Participants with the most severe O/Cs and worse performance on the Stroop task, a measure of executive function. Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan.</description><identifier>ISSN: 0022-3018</identifier><identifier>EISSN: 1539-736X</identifier><identifier>DOI: 10.1097/NMD.0b013e3181da852a</identifier><identifier>PMID: 20458194</identifier><identifier>CODEN: JNMDAN</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age Factors ; Age of Onset ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Comorbidity ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Depressive Disorder - diagnosis ; Depressive Disorder - epidemiology ; Executive Function ; Female ; Humans ; Huntington Disease - diagnosis ; Huntington Disease - epidemiology ; Huntingtons disease ; Male ; Medical diagnosis ; Medical sciences ; Medical treatment ; Middle Aged ; Morbidity ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Neuropsychological Tests - statistics & numerical data ; Neuroses ; Obsessive-Compulsive Disorder - diagnosis ; Obsessive-Compulsive Disorder - epidemiology ; Obsessive-compulsive disorders ; Organic mental disorders. Neuropsychology ; Prognosis ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Suicide - psychology</subject><ispartof>The journal of nervous and mental disease, 2010-05, Vol.198 (5), p.334-338</ispartof><rights>2010 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins May 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4543-265d462351589eb2f8a605fdeba9705f6df334c54a8fc17c86919eb66f4203a83</citedby><cites>FETCH-LOGICAL-c4543-265d462351589eb2f8a605fdeba9705f6df334c54a8fc17c86919eb66f4203a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22823668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20458194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Karen E</creatorcontrib><creatorcontrib>Gehl, Carissa R</creatorcontrib><creatorcontrib>Marder, Karen S</creatorcontrib><creatorcontrib>Beglinger, Leigh J</creatorcontrib><creatorcontrib>Paulsen, Jane S</creatorcontrib><creatorcontrib>Huntington's Study Group</creatorcontrib><title>Comorbidities of Obsessive and Compulsive Symptoms in Huntingtonʼs Disease</title><title>The journal of nervous and mental disease</title><addtitle>J Nerv Ment Dis</addtitle><description>Although current reports document a high rate of obsessive and compulsive symptoms (O/Cs) in Huntingtonʼs disease (HD), there have been no studies published that have made an attempt to identify comorbidities of O/Cs in HD. We examined O/Cs in 1642 individuals with a diagnosis of HD. Of those endorsing significant O/Cs (27.2%), nearly one-quarter reported obtaining treatment for obsessive compulsive disorder. Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individuals with HD and O/Cs endorsed significantly higher psychiatric comorbidities of depression, suicidal ideation, aggression, delusions, and hallucinations. Participants with the most severe O/Cs and worse performance on the Stroop task, a measure of executive function. Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Age of Onset</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Comorbidity</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - epidemiology</subject><subject>Executive Function</subject><subject>Female</subject><subject>Humans</subject><subject>Huntington Disease - diagnosis</subject><subject>Huntington Disease - epidemiology</subject><subject>Huntingtons disease</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Neuroses</subject><subject>Obsessive-Compulsive Disorder - diagnosis</subject><subject>Obsessive-Compulsive Disorder - epidemiology</subject><subject>Obsessive-compulsive disorders</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Prognosis</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Suicide - psychology</subject><issn>0022-3018</issn><issn>1539-736X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMFu1DAQQC0EokvhDxCKkBCnlLHHTpwj2haKaOkBkLhZTmJTlyRePEmr_htfwFfhbbdFqi8zHr8Zjx5jLzkccGjqd19ODw-gBY4Ouea91UrYR2zFFTZljdWPx2wFIESJwPUee0Z0AcBrlPCU7QmQSvNGrtjndRxjakMf5uCoiL44a8kRhUtX2Kkv8vNmGW6uX6_HzRxHKsJUHC_THKafc5z-_qHiMJCz5J6zJ94O5F7s4j77_uHo2_q4PDn7-Gn9_qTspJJYikr1shKouNKNa4XXtgLle9faps5J1XtE2Slpte943emq4ZmrKi8FoNW4z97ezt2k-HtxNJsxUOeGwU4uLmRqRIQGmi35-gF5EZc05eWMgCyp0igyJG-hLkWi5LzZpDDadG04mK1qk1Wbh6pz26vd7KUdXX_fdOc2A292gKXODj7ZqQv0nxNa3Gxw__9VHGaX6NewXLlkzp0d5nMD-ShQWRvwbQZQbkuI_wBqJpdu</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Anderson, Karen E</creator><creator>Gehl, Carissa R</creator><creator>Marder, Karen S</creator><creator>Beglinger, Leigh J</creator><creator>Paulsen, Jane S</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>Comorbidities of Obsessive and Compulsive Symptoms in Huntingtonʼs Disease</title><author>Anderson, Karen E ; Gehl, Carissa R ; Marder, Karen S ; Beglinger, Leigh J ; Paulsen, Jane S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4543-265d462351589eb2f8a605fdeba9705f6df334c54a8fc17c86919eb66f4203a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Comorbidity</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - epidemiology</topic><topic>Executive Function</topic><topic>Female</topic><topic>Humans</topic><topic>Huntington Disease - diagnosis</topic><topic>Huntington Disease - epidemiology</topic><topic>Huntingtons disease</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Neuroses</topic><topic>Obsessive-Compulsive Disorder - diagnosis</topic><topic>Obsessive-Compulsive Disorder - epidemiology</topic><topic>Obsessive-compulsive disorders</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Prognosis</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Suicide - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Karen E</creatorcontrib><creatorcontrib>Gehl, Carissa R</creatorcontrib><creatorcontrib>Marder, Karen S</creatorcontrib><creatorcontrib>Beglinger, Leigh J</creatorcontrib><creatorcontrib>Paulsen, Jane S</creatorcontrib><creatorcontrib>Huntington's Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of nervous and mental disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Karen E</au><au>Gehl, Carissa R</au><au>Marder, Karen S</au><au>Beglinger, Leigh J</au><au>Paulsen, Jane S</au><aucorp>Huntington's Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comorbidities of Obsessive and Compulsive Symptoms in Huntingtonʼs Disease</atitle><jtitle>The journal of nervous and mental disease</jtitle><addtitle>J Nerv Ment Dis</addtitle><date>2010-05</date><risdate>2010</risdate><volume>198</volume><issue>5</issue><spage>334</spage><epage>338</epage><pages>334-338</pages><issn>0022-3018</issn><eissn>1539-736X</eissn><coden>JNMDAN</coden><abstract>Although current reports document a high rate of obsessive and compulsive symptoms (O/Cs) in Huntingtonʼs disease (HD), there have been no studies published that have made an attempt to identify comorbidities of O/Cs in HD. We examined O/Cs in 1642 individuals with a diagnosis of HD. Of those endorsing significant O/Cs (27.2%), nearly one-quarter reported obtaining treatment for obsessive compulsive disorder. Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individuals with HD and O/Cs endorsed significantly higher psychiatric comorbidities of depression, suicidal ideation, aggression, delusions, and hallucinations. Participants with the most severe O/Cs and worse performance on the Stroop task, a measure of executive function. Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>20458194</pmid><doi>10.1097/NMD.0b013e3181da852a</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Age Factors Age of Onset Anxiety disorders. Neuroses Biological and medical sciences Cognition Disorders - diagnosis Cognition Disorders - epidemiology Comorbidity Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depressive Disorder - diagnosis Depressive Disorder - epidemiology Executive Function Female Humans Huntington Disease - diagnosis Huntington Disease - epidemiology Huntingtons disease Male Medical diagnosis Medical sciences Medical treatment Middle Aged Morbidity Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neuropsychological Tests - statistics & numerical data Neuroses Obsessive-Compulsive Disorder - diagnosis Obsessive-Compulsive Disorder - epidemiology Obsessive-compulsive disorders Organic mental disorders. Neuropsychology Prognosis Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Suicide - psychology |
| title | Comorbidities of Obsessive and Compulsive Symptoms in Huntingtonʼs Disease |
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