Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies
Objective To compare the difference in maternal serum anti‐Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy. Method A total of 145 pregnancies affected by foetal Down syndrome...
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| Veröffentlicht in: | Prenatal diagnosis 2010-04, Vol.30 (4), p.320-324 |
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| container_title | Prenatal diagnosis |
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| creator | Li, Hang Wun Raymond Hui, Pui Wah Tang, Mary Hoi Yin Lau, Elizabeth Tak Kwong Yeung, William Shu Biu Ho, Pak Chung Ng, Ernest Hung Yu |
| description | Objective
To compare the difference in maternal serum anti‐Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy.
Method
A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay.
Results
There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples.
Conclusions
Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross‐sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pd.2455 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733308782</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733308782</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3845-1636e6779e91d500d4d51ffc78f8f01c09ca94f920dc7b9a26245027e6a1ff543</originalsourceid><addsrcrecordid>eNp10M1u1DAUBWALgehQEG-AvEEsUIp_YjtZwgxMK02BBYil5To3U4Njp3ZCO2-PRzNtV6x8pfvpXPkg9JqSM0oI-zB2Z6wW4glaUNKqijDGn6IFoWXmjaAn6EXOvwtsWKueoxNGqBCq4Qt0d2kmSMF4nCHNAzZhctXl7D0kZwK-jmmIAbCHv-CxyzjECed5LNuY8BSxvU4xRB-3zpYMswXsAh4TdM5OLmzxKt4GnHehS3GA_WIbTLAO8kv0rDc-w6vje4p-fvn8Y3lebb6tL5YfN5XlTS0qKrkEqVQLLe0EIV3dCdr3VjV90xNqSWtNW_ctI51VV61hsvRAmAJpChM1P0XvDrljijcz5EkPLlvw3gSIc9aKc04a1bBHaVPMOUGvx-QGk3aaEr1vWY-d3rdc5Jtj5nw1QPfg7mst4O0RmFx66dP-z_nRMdUqLmVx7w_u1nnY_e-e_r46nq0O2uUJ7h60SX-0VFwJ_evrWp_L5YotP230mv8DZ7yiXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733308782</pqid></control><display><type>article</type><title>Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies</title><source>MEDLINE</source><source>Wiley Online Library (Online service)</source><creator>Li, Hang Wun Raymond ; Hui, Pui Wah ; Tang, Mary Hoi Yin ; Lau, Elizabeth Tak Kwong ; Yeung, William Shu Biu ; Ho, Pak Chung ; Ng, Ernest Hung Yu</creator><creatorcontrib>Li, Hang Wun Raymond ; Hui, Pui Wah ; Tang, Mary Hoi Yin ; Lau, Elizabeth Tak Kwong ; Yeung, William Shu Biu ; Ho, Pak Chung ; Ng, Ernest Hung Yu</creatorcontrib><description>Objective
To compare the difference in maternal serum anti‐Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy.
Method
A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay.
Results
There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples.
Conclusions
Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross‐sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.2455</identifier><identifier>PMID: 20155783</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; anti-Mullerian hormone ; Anti-Mullerian Hormone - blood ; Biological and medical sciences ; Biomarkers - blood ; Cross-Sectional Studies ; Delivery. Postpartum. Lactation ; Down syndrome ; Down Syndrome - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Mass Screening ; Maternal Age ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; pregnancy ; Pregnancy - blood ; Young Adult</subject><ispartof>Prenatal diagnosis, 2010-04, Vol.30 (4), p.320-324</ispartof><rights>Copyright © 2010 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3845-1636e6779e91d500d4d51ffc78f8f01c09ca94f920dc7b9a26245027e6a1ff543</citedby><cites>FETCH-LOGICAL-c3845-1636e6779e91d500d4d51ffc78f8f01c09ca94f920dc7b9a26245027e6a1ff543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.2455$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.2455$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22797366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20155783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Hang Wun Raymond</creatorcontrib><creatorcontrib>Hui, Pui Wah</creatorcontrib><creatorcontrib>Tang, Mary Hoi Yin</creatorcontrib><creatorcontrib>Lau, Elizabeth Tak Kwong</creatorcontrib><creatorcontrib>Yeung, William Shu Biu</creatorcontrib><creatorcontrib>Ho, Pak Chung</creatorcontrib><creatorcontrib>Ng, Ernest Hung Yu</creatorcontrib><title>Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>Objective
To compare the difference in maternal serum anti‐Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy.
Method
A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay.
Results
There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples.
Conclusions
Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross‐sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>anti-Mullerian hormone</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cross-Sectional Studies</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Down syndrome</subject><subject>Down Syndrome - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mass Screening</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>pregnancy</subject><subject>Pregnancy - blood</subject><subject>Young Adult</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1u1DAUBWALgehQEG-AvEEsUIp_YjtZwgxMK02BBYil5To3U4Njp3ZCO2-PRzNtV6x8pfvpXPkg9JqSM0oI-zB2Z6wW4glaUNKqijDGn6IFoWXmjaAn6EXOvwtsWKueoxNGqBCq4Qt0d2kmSMF4nCHNAzZhctXl7D0kZwK-jmmIAbCHv-CxyzjECed5LNuY8BSxvU4xRB-3zpYMswXsAh4TdM5OLmzxKt4GnHehS3GA_WIbTLAO8kv0rDc-w6vje4p-fvn8Y3lebb6tL5YfN5XlTS0qKrkEqVQLLe0EIV3dCdr3VjV90xNqSWtNW_ctI51VV61hsvRAmAJpChM1P0XvDrljijcz5EkPLlvw3gSIc9aKc04a1bBHaVPMOUGvx-QGk3aaEr1vWY-d3rdc5Jtj5nw1QPfg7mst4O0RmFx66dP-z_nRMdUqLmVx7w_u1nnY_e-e_r46nq0O2uUJ7h60SX-0VFwJ_evrWp_L5YotP230mv8DZ7yiXw</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Li, Hang Wun Raymond</creator><creator>Hui, Pui Wah</creator><creator>Tang, Mary Hoi Yin</creator><creator>Lau, Elizabeth Tak Kwong</creator><creator>Yeung, William Shu Biu</creator><creator>Ho, Pak Chung</creator><creator>Ng, Ernest Hung Yu</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies</title><author>Li, Hang Wun Raymond ; Hui, Pui Wah ; Tang, Mary Hoi Yin ; Lau, Elizabeth Tak Kwong ; Yeung, William Shu Biu ; Ho, Pak Chung ; Ng, Ernest Hung Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3845-1636e6779e91d500d4d51ffc78f8f01c09ca94f920dc7b9a26245027e6a1ff543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>anti-Mullerian hormone</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cross-Sectional Studies</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Down syndrome</topic><topic>Down Syndrome - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mass Screening</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>pregnancy</topic><topic>Pregnancy - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Hang Wun Raymond</creatorcontrib><creatorcontrib>Hui, Pui Wah</creatorcontrib><creatorcontrib>Tang, Mary Hoi Yin</creatorcontrib><creatorcontrib>Lau, Elizabeth Tak Kwong</creatorcontrib><creatorcontrib>Yeung, William Shu Biu</creatorcontrib><creatorcontrib>Ho, Pak Chung</creatorcontrib><creatorcontrib>Ng, Ernest Hung Yu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Hang Wun Raymond</au><au>Hui, Pui Wah</au><au>Tang, Mary Hoi Yin</au><au>Lau, Elizabeth Tak Kwong</au><au>Yeung, William Shu Biu</au><au>Ho, Pak Chung</au><au>Ng, Ernest Hung Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>2010-04</date><risdate>2010</risdate><volume>30</volume><issue>4</issue><spage>320</spage><epage>324</epage><pages>320-324</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>Objective
To compare the difference in maternal serum anti‐Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy.
Method
A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay.
Results
There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples.
Conclusions
Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross‐sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20155783</pmid><doi>10.1002/pd.2455</doi><tpages>5</tpages></addata></record> |
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| ispartof | Prenatal diagnosis, 2010-04, Vol.30 (4), p.320-324 |
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| subjects | Adult anti-Mullerian hormone Anti-Mullerian Hormone - blood Biological and medical sciences Biomarkers - blood Cross-Sectional Studies Delivery. Postpartum. Lactation Down syndrome Down Syndrome - blood Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Gestational Age Gynecology. Andrology. Obstetrics Humans Mass Screening Maternal Age Medical sciences Middle Aged Molecular and cellular biology pregnancy Pregnancy - blood Young Adult |
| title | Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies |
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