Methylene Blue for the Treatment of Septic Shock

Septic shock is a major cause of morbidity and mortality in the intensive care unit, and effective therapies are limited. Methylene blue is a selective inhibitor of guanylate cyclase, a second messenger involved in nitric oxide‐mediated vasodilation. The use of methylene blue in the treatment of sep...

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Veröffentlicht in:	Pharmacotherapy 2010-07, Vol.30 (7), p.702-715
Hauptverfasser:	Paciullo, Christopher A., Horner, Deanna McMahon, Hatton, Kevin W., Flynn, Jeremy D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacterial diseases Bacterial sepsis Biological and medical sciences Clinical Trials as Topic Dyes Emergency and intensive care: infection, septic shock Guanylate Cyclase - pharmacology Hemodynamics - drug effects Human bacterial diseases Humans Infectious diseases Intensive care medicine Lung - drug effects Medical sciences methylene blue Methylene Blue - pharmacology Nitric Oxide - pharmacology Pharmacology. Drug treatments Randomized Controlled Trials as Topic Retrospective Studies Sepsis septic shock Shock, Septic - drug therapy Shock, Septic - physiopathology Vasodilation - drug effects vasodilatory shock vasopressor
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